Concepedia

Dose-dependent Elimination

Dose-Dependent Elimination is a pharmacokinetic elimination process in which the rate or extent of drug clearance from the body changes disproportionately with dose due to saturation of metabolic or excretory mechanisms.

122

Publications

6.9K

Citations

544

Authors

184

Institutions

Publications per year

2017–2026

7

Variants

Nonlinear EliminationSaturable Elimination

Parents

Publications

122

A core function for p120-catenin in cadherin turnover

Michael A. Davis, Reneé C. Ireton, Albert B. Reynolds · The Journal of Cell Biology · 2003 · 728 citations · Full text

, , +15

Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation.

Volker Heinemann, Yi-Zheng Xu, Sherri Chubb et al. · PubMed · 1992 · 330 citations

, , +17

Human Pharmacokinetics and Safety Evaluation of SonoVue™, a New Contrast Agent for Ultrasound Imaging

Denis R. Morel, Ian M. Schwieger, Laurent Höhn et al. · Investigative Radiology · 2000 · 254 citations

, , +15

Aryl Hydrocarbon Receptor-Dependent Induction of Cyp1a1 by Bilirubin in Mouse Hepatoma Hepa 1c1c7 Cells

Christopher J. Sinal, John R. Bend · Molecular Pharmacology · 1997 · 251 citations

, , +16

Single- and Multiple-Dose Pharmacokinetics of Caspofungin in Healthy Men

Julie A. Stone, Sherry D. Holland, Peter Wickersham et al. · Antimicrobial Agents and Chemotherapy · 2002 · 247 citations · Full text

, , +15

1–5 of 122

Authors

544

  1. GL
    Gerhard Levy

    University at Buffalo, State University of New York, United States

    3 publications · 140 citations

    3

    h-index

  2. SA
    Shirley Anderson

    University of Texas Health Science Center at Dallas, United States

    2 publications · 86 citations

    2

    h-index

  3. DC
    D. Craig Brater

    Indiana University – Purdue University Indianapolis, United States

    2 publications · 86 citations

    2

    h-index

  4. JE
    Jerome Edelson

    Sterling Research Group (United States), United States

    2 publications · 64 citations

    2

    h-index

  5. LS
    Linda S. Birnbaum

    National Institute of Environmental Health Sciences, United States

    2 publications · 146 citations

    2

    h-index

1–5 of 544

Institutions

184

  1. Karolinska Institutet

    Stockholm, Sweden

    4 h-index

    18 publications

    802 citations

  2. Research Triangle Park Foundation

    Durham, United States

    3 h-index

    7 publications

    473 citations

  3. University at Buffalo, State University of New York

    Buffalo, United States

    3 h-index

    5 publications

    209 citations

  4. Cornell University

    Ithaca, United States

    3 h-index

    11 publications

    1.3K citations

  5. National Institute of Environmental Health Sciences

    Durham, United States

    2 h-index

    2 publications

    107 citations

  6. The University of Texas Southwestern Medical Center

    Dallas, United States

    2 h-index

    4 publications

    151 citations

  7. Johns Hopkins University

    Baltimore, United States

    2 h-index

    8 publications

    584 citations

  8. Newport Hospital

    Newport, United States

    2 h-index

    2 publications

    60 citations

1–8 of 184

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 12 publications · 805 citations

    12

    h-index

  2. PubMed

    Repository · 11 publications · 612 citations

    11

    h-index

  3. Drug Metabolism and Disposition

    9 publications · 335 citations

    9

    h-index

  4. Antimicrobial Agents and Chemotherapy

    AAC · 7 publications · 699 citations

    7

    h-index

  5. Journal of Pharmaceutical Sciences

    6 publications · 272 citations

    6

    h-index

1–5