Concepedia

Dose Optimization Trials

Dose Optimization Trials is a type of clinical trial design that systematically evaluates varying dosage levels of a therapeutic intervention to identify the optimal dose that maximizes efficacy while minimizing adverse effects within a target population.

16

Publications

1.1K

Citations

131

Authors

73

Institutions

Publications per year

2017–2026

13

Variants

Dose-finding TrialsDose-ranging Studies

Parents

Publications

16

Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study

Tanios Bekaii‐Saab, Fang‐Shu Ou, Daniel H. Ahn et al. · The Lancet Oncology · 2019 · 284 citations · Full text

, , +12

The Drug-Dosing Conundrum in Oncology — When Less Is More

Mirat Shah, Atiqur Rahman, Marc R. Theoret et al. · New England Journal of Medicine · 2021 · 278 citations

, , +17

Translation of Innovative Designs Into Phase I Trials

André Rogatko, David J. Schoeneck, William Jonas et al. · Journal of Clinical Oncology · 2007 · 220 citations · Full text

, , +17

Project Optimus, an FDA initiative: Considerations for cancer drug development internationally, from an academic perspective

Ravindhi Murphy, Sarah Halford, Stefan N. Symeonides · Frontiers in Oncology · 2023 · 53 citations · Full text

, , +17

Dose Optimization of Sotorasib: Is the US Food and Drug Administration Sending a Message?

Mark J. Ratain, Ian F. Tannock, Allen S. Lichter · Journal of Clinical Oncology · 2021 · 41 citations

, , +10

1–5 of 16

Authors

131

  1. RL
    Ruitao Lin

    The University of Texas MD Anderson Cancer Center, United States

    1 publications · 20 citations

    1

    h-index

  2. RW
    Richard W. Light

    Vanderbilt University, United States

    1 publications · 26 citations

    1

    h-index

  3. IA
    Isabelle Aerts

    Institut Curie, France

    1 publications · 23 citations

    1

    h-index

  4. JT
    Jacob T. Beckley

    Medical University of South Carolina, United States

    1 publications · 41 citations

    1

    h-index

  5. DL
    Daniel Li

    Université d'Artois, France

    1 publications · 20 citations

    1

    h-index

1–5 of 131

Institutions

73

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    2 h-index

    5 publications

    90 citations

  2. Case Western Reserve University

    Cleveland, United States

    2 h-index

    6 publications

    131 citations

  3. Rice University

    Houston, United States

    2 h-index

    3 publications

    50 citations

  4. Hospital de León

    León, Spain

    1 h-index

    1 publications

    18 citations

  5. Pfizer (United States)

    New York, United States

    1 h-index

    1 publications

    20 citations

  6. Cairns Hospital

    Cairns, Australia

    1 h-index

    1 publications

    26 citations

  7. Université Paris Cité

    Paris, France

    1 h-index

    1 publications

    23 citations

  8. Atrium Health Wake Forest Baptist

    Winston-Salem, United States

    1 h-index

    2 publications

    568 citations

1–8 of 73

Venues

  1. Journal of Clinical Oncology

    3 publications · 292 citations

    3

    h-index

  2. Frontiers in Oncology

    1 publications · 53 citations

    1

    h-index

  3. Digestive Diseases and Sciences

    1 publications · 24 citations

    1

    h-index

  4. JCI Insight

    1 publications · 26 citations

    1

    h-index

  5. Biometrics

    1 publications · 15 citations

    1

    h-index

1–5