Concepedia

Dosage-sensitive Lethality

Dosage-Sensitive Lethality is a genetic phenomenon in which the viability of an organism is critically dependent on the precise copy number or expression level of a particular gene, such that deviations from the normal dosage—either haploinsufficiency or overexpression—result in embryonic lethality.

15

Publications

1.6K

Citations

72

Authors

29

Institutions

Publications per year

2017–2026

0

Parents

Publications

15

Overlapping and Unique Roles for C-Terminal Binding Protein 1 (CtBP1) and CtBP2 during Mouse Development

Jeffrey D. Hildebrand, Philippe Soriano · Molecular and Cellular Biology · 2002 · 300 citations · Full text

, , +11

enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties.

Frank B. Gertler, Allen R. Comer, Jyh‐Lyh Juang et al. · Genes & Development · 1995 · 258 citations · Full text

, , +16

Establishing Genetic Interactions by a Synthetic Dosage Lethality Phenotype

Eugene S Kroll, Katherine Hyland, Philip Hieter et al. · Genetics · 1996 · 169 citations · Full text

, , +14

A Drosophila Homolog of the Polyglutamine Disease Gene <i>SCA2</i> Is a Dosage-Sensitive Regulator of Actin Filament Formation

Terrence F. Satterfield, Stephen M. Jackson, Leo J. Pallanck · Genetics · 2002 · 140 citations · Full text

, , +17

Lethal arrhythmias in <i>Tbx3</i> -deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

Deborah U. Frank, Kandis L. Carter, Kirk R. Thomas et al. · Proceedings of the National Academy of Sciences · 2011 · 139 citations · Full text

, , +17

1–5 of 15

Authors

72

  1. KH
    Katherine Hyland

    University of British Columbia, Canada

    3 publications · 402 citations

    3

    h-index

  2. PH
    Philip Hieter

    Johns Hopkins University, United States

    3 publications · 402 citations

    3

    h-index

  3. DB
    Daniel Bachiller

    Consejo Superior de Investigaciones Científicas, Spain

    1 publications · 12 citations

    1

    h-index

  4. IP
    Isabelle Pot

    University of British Columbia, Canada

    1 publications · 124 citations

    1

    h-index

  5. KL
    Kandis L. Carter

    University of Utah, United States

    1 publications · 139 citations

    1

    h-index

1–5 of 72

Institutions

29

  1. University of Washington

    Seattle, United States

    4 h-index

    17 publications

    2.2K citations

  2. University of British Columbia

    Vancouver, Canada

    2 h-index

    13 publications

    1.6K citations

  3. Johns Hopkins University

    Baltimore, United States

    2 h-index

    7 publications

    943 citations

  4. University of Amsterdam

    Amsterdam, The Netherlands

    1 h-index

    2 publications

    278 citations

  5. Institute of Cytology and Genetics

    Novosibirsk, Russia

    1 h-index

    1 publications

    51 citations

  6. Centro de Investigaciones Biológicas Margarita Salas

    Madrid, Spain

    1 h-index

    2 publications

    24 citations

  7. Amsterdam UMC Location University of Amsterdam

    Amsterdam, The Netherlands

    1 h-index

    2 publications

    278 citations

  8. New York University

    New York, United States

    1 h-index

    1 publications

    139 citations

1–8 of 29

Venues

  1. Genetics

    4 publications · 381 citations

    4

    h-index

  2. Genes & Development

    2 publications · 382 citations

    2

    h-index

  3. Molecular and General Genetics MGG

    1 publications · 17 citations

    1

    h-index

  4. Molecular and Cellular Biology

    MCB · 1 publications · 300 citations

    1

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 139 citations

    1

    h-index

1–5