Concepedia

Dissolution-permeation Interplay

Dissolution-Permeation Interplay is a pharmacokinetic framework that characterizes the dynamic interdependence between the rate of drug dissolution in the gastrointestinal milieu and the subsequent rate of drug permeation across biological membranes, distinguishing it from isolated dissolution or permeation models by integrating their concurrent influence on oral drug absorption.

142

Publications

11.4K

Citations

610

Authors

186

Institutions

Publications per year

2017–2026

42

Parents

Publications

142

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al. · Pharmaceutical Research · 1995 · 5.3K citations · Full text

, , +16

Pharmacokinetics of Celecoxib after Oral Administration in Dogs and Humans: Effect of Food and Site of Absorption

Susan K. Paulson, Margaret B. Vaughn, Susan M. Jessen et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 286 citations

, , +17

The Solubility–Permeability Interplay in Using Cyclodextrins as Pharmaceutical Solubilizers: Mechanistic Modeling and Application to Progesterone

Arik Dahan, Jonathan M. Miller, Amnon Hoffman et al. · Journal of Pharmaceutical Sciences · 2009 · 221 citations · Full text

, , +17

Link between drug absorption solubility and permeability measurements in Caco-2 cells

Vaishali Pade, Salomon Stavchansky · Journal of Pharmaceutical Sciences · 1998 · 187 citations

, , +16

Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses

Grzegorz Garbacz, Ralph‐Steven Wedemeyer, Stefan Nagel et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2008 · 162 citations

, , +17

1–5 of 142

Authors

610

  1. MB
    Martin Brandl

    University of Southern Denmark, Denmark

    13 publications · 501 citations

    13

    h-index

  2. SY
    Shinji Yamashita

    Setsunan University, Japan

    11 publications · 574 citations

    11

    h-index

  3. AB
    Annette Bauer‐Brandl

    University of Southern Denmark, Denmark

    11 publications · 315 citations

    11

    h-index

  4. MK
    Makoto Kataoka

    Setsunan University, Japan

    10 publications · 547 citations

    10

    h-index

  5. PA
    Patrick Augustijns

    KU Leuven, Belgium

    8 publications · 532 citations

    8

    h-index

1–5 of 610

Institutions

186

  1. University of Southern Denmark

    Odense, Denmark

    13 h-index

    41 publications

    1.4K citations

  2. Setsunan University

    Osaka, Japan

    10 h-index

    45 publications

    2.5K citations

  3. KU Leuven

    Leuven, Belgium

    9 h-index

    27 publications

    1.8K citations

  4. University of Copenhagen

    Copenhagen, Denmark

    5 h-index

    10 publications

    181 citations

  5. University of Michigan

    Ann Arbor, United States

    4 h-index

    15 publications

    6.9K citations

  6. Purdue University West Lafayette

    West Lafayette, United States

    4 h-index

    9 publications

    589 citations

  7. AbbVie (Germany)

    Wiesbaden, Germany

    4 h-index

    8 publications

    658 citations

  8. Johannes Gutenberg University Mainz

    Mainz, Germany

    4 h-index

    9 publications

    324 citations

1–8 of 186

Venues

  1. Journal of Pharmaceutical Sciences

    27 publications · 1.4K citations

    21

    h-index

  2. International Journal of Pharmaceutics

    25 publications · 1.1K citations

    19

    h-index

  3. European Journal of Pharmaceutical Sciences

    18 publications · 684 citations

    15

    h-index

  4. European Journal of Pharmaceutics and Biopharmaceutics

    EJPB · 11 publications · 630 citations

    11

    h-index

  5. Pharmaceutical Research

    5 publications · 5.7K citations

    5

    h-index

1–5