Concepedia

Disease-modifying Therapy Development

Disease-Modifying Therapy Development is a research-driven process in neuromuscular disorder pharmacotherapy that involves the design, validation, and translation of therapeutic interventions aimed at altering the underlying pathophysiology of the disease, thereby slowing, halting, or reversing its progression, as distinct from symptomatic treatment approaches.

390

Publications

18.5K

Citations

3.2K

Authors

1.2K

Institutions

Publications per year

2017–2026

209

Parents

Publications

390

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

Lars Lannfelt, Kaj Blennow, Henrik Zetterberg et al. · The Lancet Neurology · 2008 · 712 citations

, , +17

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

Manuela Battaglia, Simi Ahmed, Mark S. Anderson et al. · Diabetes Care · 2019 · 344 citations · Full text

, , +12

Down syndrome and Alzheimer's disease: Common pathways, common goals

Dean M. Hartley, Thomas Blumenthal, María C. Carrillo et al. · Alzheimer s & Dementia · 2014 · 302 citations

, , +17

Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis

Richard K. Burt, Roumen Balabanov, Joachim Burman et al. · JAMA · 2019 · 300 citations · Full text

, , +14

Preclinical Characterization of<sup>18</sup>F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

Eric D. Hostetler, Abbas Walji, Zhizhen Zeng et al. · Journal of Nuclear Medicine · 2016 · 284 citations · Full text

, , +17

1–5 of 390

Authors

3.2K

  1. FP
    Francesco Patti

    University of Catania, Italy

    6 publications · 198 citations

    6

    h-index

  2. EH
    Eva Havrdová

    Charles University, Czechia

    5 publications · 174 citations

    5

    h-index

  3. LK
    Lauren Krupp

    Stony Brook University, United States

    4 publications · 404 citations

    4

    h-index

  4. JR
    John Rose

    University of Utah, United States

    5 publications · 703 citations

    4

    h-index

  5. JL
    Jeffrey L. Cummings

    University of California, Los Angeles, United States

    4 publications · 268 citations

    4

    h-index

1–5 of 3.2K

Institutions

1.2K

  1. University College London

    London, United Kingdom

    17 h-index

    61 publications

    2.9K citations

  2. Inserm

    Paris, France

    13 h-index

    23 publications

    1.5K citations

  3. University of Toronto

    Toronto, Canada

    12 h-index

    18 publications

    784 citations

  4. Northwestern University

    Evanston, United States

    11 h-index

    35 publications

    5.2K citations

  5. Massachusetts General Hospital

    Boston, United States

    11 h-index

    42 publications

    5K citations

  6. Harvard University

    Cambridge, United States

    11 h-index

    36 publications

    2.5K citations

  7. University of Pennsylvania

    Philadelphia, United States

    11 h-index

    17 publications

    832 citations

  8. Cleveland Clinic

    Cleveland, United States

    10 h-index

    47 publications

    2.7K citations

1–8 of 1.2K

Venues

  1. PubMed

    Repository · 25 publications · 844 citations

    15

    h-index

  2. Neurology

    9 publications · 364 citations

    9

    h-index

  3. Journal of Medicinal Chemistry

    8 publications · 624 citations

    8

    h-index

  4. Multiple Sclerosis and Related Disorders

    7 publications · 225 citations

    7

    h-index

  5. Journal of Alzheimer s Disease

    JAD · 7 publications · 209 citations

    7

    h-index

1–5