Concepedia

Directed Recombination

Directed Recombination is a computational method in the field of diversity generation that systematically combines genetic or structural elements from distinct sources under specific guidance or constraints to produce novel variants with targeted properties, distinguishing it from random recombination approaches by its purposeful and controlled mechanism.

36

Publications

2.5K

Citations

149

Authors

53

Institutions

Publications per year

2017–2026

5

Parents

Publications

36

Mice Lacking TdT: Mature Animals with an Immature Lymphocyte Repertoire

Susan Gilfillan, Andrée Dierich, Marianne LeMeur et al. · Science · 1993 · 450 citations

, , +17

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination.

Thierry Hennet, Fred K. Hagen, Lawrence A. Tabak et al. · Proceedings of the National Academy of Sciences · 1995 · 270 citations

, , +16

Targeted mutation of the Hprt gene in mouse embryonic stem cells.

Thomas Doetschman, Nobuo Maeda, Oliver Smithies · Proceedings of the National Academy of Sciences · 1988 · 224 citations · Full text

, , +14

Random-priming in vitro recombination: An effective tool for directed evolution

Zongze Shao, Hongwei Zhao, Lori Giver et al. · Nucleic Acids Research · 1998 · 177 citations · Full text

, , +16

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

Malika Hale, Taylor D. Mesojednik, Guillermo S. Romano Ibarra et al. · Molecular Therapy · 2017 · 166 citations · Full text

, , +17

1–5 of 36

Authors

149

  1. NL
    Niles Lehman

    Portland State University, United States

    3 publications · 117 citations

    3

    h-index

  2. CA
    Craig A. Riley

    Portland State University, United States

    2 publications · 103 citations

    2

    h-index

  3. AJ
    Ann J. Feeney

    Scripps Research Institute, United States

    2 publications · 45 citations

    2

    h-index

  4. FH
    Frances H. Arnold

    California Institute of Technology, United States

    2 publications · 266 citations

    2

    h-index

  5. KJ
    Karl‐Erich Jaeger

    Heinrich Heine University Düsseldorf, Germany

    2 publications · 69 citations

    2

    h-index

1–5 of 149

Institutions

53

  1. Heinrich Heine University Düsseldorf

    Düsseldorf, Germany

    3 h-index

    11 publications

    213 citations

  2. Portland State University

    Portland, United States

    3 h-index

    8 publications

    320 citations

  3. Scripps Research Institute

    San Diego, United States

    3 h-index

    9 publications

    292 citations

  4. University of California, Berkeley

    Berkeley, United States

    2 h-index

    5 publications

    392 citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    6 publications

    1.2K citations

  6. Forschungszentrum Jülich

    Jülich, Germany

    2 h-index

    4 publications

    129 citations

  7. California Institute of Technology

    Pasadena, United States

    2 h-index

    5 publications

    797 citations

  8. The University of Texas Southwestern Medical Center

    Dallas, United States

    1 h-index

    4 publications

    180 citations

1–8 of 53

Venues

  1. Nucleic Acids Research

    3 publications · 257 citations

    3

    h-index

  2. The Journal of Immunology

    JI · 2 publications · 63 citations

    2

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 494 citations

    2

    h-index

  4. PubMed

    Repository · 2 publications · 48 citations

    2

    h-index

  5. Advances in biochemical engineering, biotechnology

    Book series · 1 publications · 24 citations

    1

    h-index

1–5