Concepedia

Directed Evolution Optimization

Directed Evolution Optimization is a computational optimization method that belongs to the class of evolutionary algorithms, distinguished by its systematic incorporation of experimental feedback from successive generations of variant selection to guide the search process toward improved fitness peaks in a high-dimensional landscape.

228

Publications

14.4K

Citations

1.2K

Authors

352

Institutions

Publications per year

2017–2026

71

Parents

Publications

228

DNA shuffling of a family of genes from diverse species accelerates directed evolution

Andreas Crameri, Sun-Ai Raillard, Ericka Bermudez et al. · Nature · 1998 · 828 citations

, , +13

Directed evolution of an efficient and thermostable PET depolymerase

Elizabeth L. Bell, Ross Smithson, Siobhan Kilbride et al. · Nature Catalysis · 2022 · 430 citations · Full text

, , +7

Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents

Jeffrey C. Moore, Frances H. Arnold · Nature Biotechnology · 1996 · 424 citations

, , +15

Directed evolution of a monomeric, bright and photostable version of <i>Clavularia</i> cyan fluorescent protein: structural characterization and applications in fluorescence imaging

Hui‐wang Ai, J. Nathan Henderson, S. James Remington et al. · Biochemical Journal · 2006 · 401 citations · Full text

, , +12

Discovery and Directed Evolution of a Glyphosate Tolerance Gene

Linda A. Castle, Daniel L. Siehl, Rebecca Gorton et al. · Science · 2004 · 327 citations

, , +12

1–5 of 228

Authors

1.2K

  1. FH
    Frances H. Arnold

    California Institute of Technology, United States

    7 publications · 977 citations

    7

    h-index

  2. DS
    Dan S. Tawfik

    Weizmann Institute of Science, Israel

    6 publications · 891 citations

    6

    h-index

  3. HZ
    Huimin Zhao

    University of Illinois Urbana-Champaign, United States

    5 publications · 208 citations

    5

    h-index

  4. US
    Ulrich Schwaneberg

    RWTH Aachen University, Germany

    5 publications · 241 citations

    5

    h-index

  5. RE
    Robert E. Campbell

    University of Alberta, Canada

    5 publications · 562 citations

    5

    h-index

1–5 of 1.2K

Institutions

352

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    28 publications

    3.6K citations

  2. Weizmann Institute of Science

    Rehovot, Israel

    9 h-index

    37 publications

    5.4K citations

  3. California Institute of Technology

    Pasadena, United States

    8 h-index

    37 publications

    4.3K citations

  4. Scripps Research Institute

    San Diego, United States

    7 h-index

    18 publications

    2.5K citations

  5. RWTH Aachen University

    Aachen, Germany

    7 h-index

    26 publications

    1.1K citations

  6. University of Washington

    Seattle, United States

    6 h-index

    18 publications

    2.5K citations

  7. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    28 publications

    1.4K citations

  8. Zhejiang University

    Hangzhou, China

    6 h-index

    30 publications

    842 citations

1–8 of 352

Venues

  1. Applied Microbiology and Biotechnology

    15 publications · 644 citations

    14

    h-index

  2. Journal of Biotechnology

    13 publications · 873 citations

    13

    h-index

  3. Journal of Molecular Biology

    JMB · 9 publications · 843 citations

    9

    h-index

  4. Journal of Biological Chemistry

    JBC · 9 publications · 378 citations

    9

    h-index

  5. Chemistry & Biology

    8 publications · 554 citations

    8

    h-index

1–5