Concepedia

Desensitization Modeling

Desensitization Modeling is a computational framework within signal transduction modeling that specifically characterizes the dynamic attenuation of cellular response to persistent or repeated stimulation, distinguishing itself by quantifying regulatory mechanisms such as receptor internalization, feedback inhibition, and adaptation processes.

44

Publications

2.9K

Citations

148

Authors

67

Institutions

Publications per year

2017–2026

4

Parents

Publications

44

Relative efficacy of desensitization and modeling approaches for inducing behavioral, affective, and attitudinal changes.

Albert Bandura, Edward B. Blanchard, Brunhilde Ritter · Journal of Personality and Social Psychology · 1969 · 570 citations

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NMDA channel behavior depends on agonist affinity

R.A.J. Lester, CE Jahr · Journal of Neuroscience · 1992 · 401 citations · Full text

, , +17

A Computational Study of Feedback Effects on Signal Dynamics in a Mitogen‐Activated Protein Kinase (MAPK) Pathway Model

Anand R. Asthagiri, Douglas A. Lauffenburger · Biotechnology Progress · 2001 · 192 citations

, , +17

Studies in desensitization—I: The separate effects of relaxation and desensitization

S. Rachman · Behaviour Research and Therapy · 1965 · 168 citations

, , +8

Desensitization of mechano-gated K <sub>2P</sub> channels

Éric Honoré, Amanda J. Patel, Jean Chemin et al. · Proceedings of the National Academy of Sciences · 2006 · 131 citations · Full text

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1–5 of 44

Authors

148

  1. DC
    David Colquhoun

    University College London, United Kingdom

    2 publications · 132 citations

    2

    h-index

  2. AV
    Ana V. Paternain

    Consejo Superior de Investigaciones Científicas, Spain

    1 publications · 112 citations

    1

    h-index

  3. CR
    Clark Rb

    Johns Hopkins University, United States

    1 publications · 20 citations

    1

    h-index

  4. AL
    Allison L. Germann

    Taylor Family Institute for Innovative Psychiatric Research

    1 publications · 23 citations

    1

    h-index

  5. CD
    Carmen Dessauer

    The University of Texas Health Science Center at Houston, United States

    1 publications · 24 citations

    1

    h-index

1–5 of 148

Institutions

67

  1. University College London

    London, United Kingdom

    2 h-index

    6 publications

    472 citations

  2. Penny George Institute for Health and Healing

    Minneapolis, United States

    1 h-index

    2 publications

    96 citations

  3. Institut de Pharmacologie Moléculaire et Cellulaire

    Valbonne, France

    1 h-index

    2 publications

    262 citations

  4. New York University

    New York, United States

    1 h-index

    2 publications

    34 citations

  5. Taylor Family Institute for Innovative Psychiatric Research

    St Louis, United States

    1 h-index

    5 publications

    115 citations

  6. University Hospital Heidelberg

    Heidelberg, Germany

    1 h-index

    4 publications

    88 citations

  7. University at Buffalo, State University of New York

    Buffalo, United States

    1 h-index

    2 publications

    262 citations

  8. Heidelberg University

    Heidelberg, Germany

    1 h-index

    8 publications

    176 citations

1–8 of 67

Venues

  1. Behaviour Research and Therapy

    6 publications · 353 citations

    6

    h-index

  2. Journal of Theoretical Biology

    4 publications · 139 citations

    4

    h-index

  3. Molecular Pharmacology

    3 publications · 101 citations

    3

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 207 citations

    3

    h-index

  5. PubMed

    Repository · 2 publications · 61 citations

    2

    h-index

1–5