Concepedia

Descending Itch Modulation

Descending Itch Modulation is a neurophysiological mechanism within the central nervous system that refers to the top-down inhibitory or facilitatory control exerted by supraspinal brain regions on spinal itch transmission, thereby regulating the perception and behavioral response to pruritic stimuli.

6

Publications

312

Citations

50

Authors

20

Institutions

Publications per year

2017–2026

3

Parents

Publications

6

Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling

Zhongqiu Zhao, Xianyu Liu, Joseph Jeffry et al. · Neuron · 2014 · 135 citations · Full text

, , +16

Decreased pain inhibition in irritable bowel syndrome depends on altered descending modulation and higher-order brain processes

Mathieu Piché, Mickaël Bouin, Marianne Arsenault et al. · Neuroscience · 2011 · 70 citations

, , +17

Differential roles of prelimbic and anterior cingulate cortical region in the modulation of histaminergic and non-histaminergic itch

Xuan Li, Juan Yao, Ke-hui Hu et al. · Behavioural Brain Research · 2021 · 31 citations

, , +14

GRPR/Extracellular Signal–Regulated Kinase and NPRA/Extracellular Signal–Regulated Kinase Signaling Pathways Play a Critical Role in Spinal Transmission of Chronic Itch

Xueting Liu, Tianyu Tao, Liping Zeng et al. · Journal of Investigative Dermatology · 2020 · 28 citations · Full text

, , +17

Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice

K. Koga, Yuto Shiraishi, Ryo Yamagata et al. · Molecular Brain · 2020 · 27 citations · Full text

, , +17

1–5 of 6

Authors

50

  1. ZZ
    Zhongqiu Zhao

    Washington University in St. Louis, United States

    2 publications · 163 citations

    2

    h-index

  2. JY
    Juan Yao

    Army Medical University, China

    1 publications · 31 citations

    1

    h-index

  3. YS
    Yuto Shiraishi

    Kyushu University, Japan

    1 publications · 27 citations

    1

    h-index

  4. KK
    K. Koga

    Kyushu University, Japan

    1 publications · 27 citations

    1

    h-index

  5. MS
    Miho Shiratori‐Hayashi

    Kyushu University, Japan

    1 publications · 27 citations

    1

    h-index

1–5 of 50

Institutions

20

  1. Washington University in St. Louis

    St Louis, United States

    2 h-index

    17 publications

    2.2K citations

  2. Université de Montréal

    Montreal, Canada

    1 h-index

    3 publications

    210 citations

  3. Southern Medical University

    Guangzhou, China

    1 h-index

    1 publications

    135 citations

  4. University of Toyama

    Toyama, Japan

    1 h-index

    3 publications

    63 citations

  5. Guangzhou Medical University

    Guangzhou, China

    1 h-index

    8 publications

    224 citations

  6. Kyushu University

    Fukuoka, Japan

    1 h-index

    6 publications

    162 citations

  7. Army Medical University

    Chongqing, China

    1 h-index

    7 publications

    217 citations

  8. Hyogo Medical University

    Nishinomiya, Japan

    1 h-index

    1 publications

    27 citations

1–8 of 20

Venues

  1. Behavioural Brain Research

    1 publications · 31 citations

    1

    h-index

  2. Neuron

    1 publications · 135 citations

    1

    h-index

  3. Journal of Investigative Dermatology

    JID · 1 publications · 28 citations

    1

    h-index

  4. Molecular Brain

    1 publications · 27 citations

    1

    h-index

  5. Journal of Pharmacological Sciences

    1 publications · 21 citations

    1

    h-index

1–5