Concepedia

Deregulated Nutrient Sensing

Deregulated Nutrient Sensing is an age-related molecular dysfunction characterized by the impaired signaling of cellular nutrient availability, in which the attenuation or hyperactivity of conserved pathways such as insulin/IGF-1, mTOR, AMPK, and sirtuins disrupts metabolic homeostasis and contributes to the progression of aging and age-associated diseases.

21

Publications

1.3K

Citations

140

Authors

81

Institutions

Publications per year

2017–2026

12

Parents

Publications

21

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling

Janet Ugolino, Yon Ju Ji, Karen Conchina et al. · PLoS Genetics · 2016 · 189 citations · Full text

, , +17

The human sirtuin family: Evolutionary divergences and functions

Athanassios Vassilopoulos, Kristofer S. Fritz, Dennis R. Petersen et al. · Human Genomics · 2011 · 189 citations · Full text

, , +8

Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress

Richard C. Scarpulla · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · 2011 · 166 citations

, , +17

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

Javier A. Menéndez, Jorge Joven, Gerard Aragonès et al. · Cell Cycle · 2013 · 147 citations · Full text

, , +16

Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men

Antoneta Granic, Karen Suetterlin, Tea Shavlakadze et al. · Clinical Science · 2023 · 94 citations · Full text

, , +17

1–5 of 21

Authors

140

  1. MH
    María Herranz‐López

    Universitat de Miguel Hernández d'Elx, Spain

    1 publications · 147 citations

    1

    h-index

  2. AH
    Anna Hernández‐Aguilera

    Institut de Recerca Biomèdica Catalunya Sud, Spain

    1 publications · 147 citations

    1

    h-index

  3. BK
    Brian K. Kennedy

    Buck Institute for Research on Aging, United States

    1 publications · 21 citations

    1

    h-index

  4. SG
    Salil Ghosh

    National Institutes of Health, United States

    1 publications · 44 citations

    1

    h-index

  5. NV
    Nicola Veronese

    National Research Council, Italy

    1 publications · 60 citations

    1

    h-index

1–5 of 140

Institutions

81

  1. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    7 publications

    510 citations

  2. Broad Institute

    Cambridge, United States

    2 h-index

    2 publications

    115 citations

  3. Southwest University

    Chongqing, China

    1 h-index

    1 publications

    21 citations

  4. Arizona State University

    Tempe, United States

    1 h-index

    4 publications

    64 citations

  5. The University of Queensland

    Brisbane, Australia

    1 h-index

    1 publications

    36 citations

  6. Suzhou Research Institute

    Suzhou, China

    1 h-index

    4 publications

    84 citations

  7. Georgetown University

    Washington, United States

    1 h-index

    1 publications

    44 citations

  8. Foie, Métabolisme, Cancer

    Rennes, France

    1 h-index

    5 publications

    735 citations

1–8 of 81

Venues

  1. Cell Cycle

    2 publications · 190 citations

    2

    h-index

  2. Indian Journal of Biochemistry and Biophysics

    1 publications · 15 citations

    1

    h-index

  3. PLoS ONE

    1 publications · 44 citations

    1

    h-index

  4. Clinical Science

    1 publications · 94 citations

    1

    h-index

  5. Mechanisms of Ageing and Development

    1 publications · 18 citations

    1

    h-index

1–5