Concepedia

Deleterious Mutation Accumulation

Deleterious Mutation Accumulation is a theoretical model in evolutionary genetics that describes the process by which harmful mutations persist and increase in frequency within a population due to weakened purifying selection, particularly in non-recombining genomic regions or small populations.

739

Publications

69K

Citations

2.6K

Authors

939

Institutions

Publications per year

2017–2026

170

Parents

Publications

739

THE EVOLUTIONARY ADVANTAGE OF RECOMBINATION

Joseph Felsenstein · Genetics · 1974 · 1.8K citations · Full text

, , +17

Genetic compensation induced by deleterious mutations but not gene knockdowns

Andrea Rossi, Zacharias Kontarakis, Claudia Gerri et al. · Nature · 2015 · 1.3K citations

, , +14

Chromosome Inversions, Local Adaptation and Speciation

Mark Kirkpatrick, Nick Barton · Genetics · 2005 · 1.3K citations · Full text

, , +13

Mutation Accumulation and the Extinction of Small Populations

Michael Lynch, John S. Conery, Reinhard Bürger · The American Naturalist · 1995 · 1.1K citations

, , +15

Accelerated evolution and Muller's rachet in endosymbiotic bacteria.

Nancy A. Moran · Proceedings of the National Academy of Sciences · 1996 · 1.1K citations

, , +15

1–5 of 739

Authors

2.6K

  1. ML
    Michael Lynch

    Indiana University Bloomington, United States

    23 publications · 5.7K citations

    22

    h-index

  2. BC
    Brian Charlesworth

    University of Edinburgh, United Kingdom

    15 publications · 3.1K citations

    15

    h-index

  3. PD
    Peter D. Keightley

    University of Edinburgh, United Kingdom

    13 publications · 2K citations

    13

    h-index

  4. SF
    Santiago F. Elena

    Instituto de Biología Molecular y Celular de Plantas, Spain

    11 publications · 1.3K citations

    10

    h-index

  5. IG
    Isabel Gordo

    Instituto Gulbenkian de Ciência, Portugal

    10 publications · 872 citations

    10

    h-index

1–5 of 2.6K

Institutions

939

  1. University of Edinburgh

    Edinburgh, United Kingdom

    28 h-index

    72 publications

    10.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    23 h-index

    103 publications

    3.4K citations

  3. Cornell University

    Ithaca, United States

    22 h-index

    69 publications

    8.5K citations

  4. University of Oregon

    Eugene, United States

    22 h-index

    47 publications

    7.5K citations

  5. Harvard University

    Cambridge, United States

    19 h-index

    51 publications

    7.6K citations

  6. University of Toronto

    Toronto, Canada

    18 h-index

    41 publications

    3.4K citations

  7. Uppsala University

    Uppsala, Sweden

    17 h-index

    44 publications

    4.3K citations

  8. Indiana University Bloomington

    Bloomington, United States

    17 h-index

    29 publications

    3.3K citations

1–8 of 939

Venues

  1. Genetics

    84 publications · 9.4K citations

    48

    h-index

  2. Evolution

    68 publications · 5.1K citations

    39

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 45 publications · 8.8K citations

    39

    h-index

  4. Molecular Biology and Evolution

    MBE · 45 publications · 3.7K citations

    31

    h-index

  5. Journal of Evolutionary Biology

    JEB · 26 publications · 996 citations

    21

    h-index

1–5