Concepedia

Degeneration Model

The "Degeneration Model" is a theoretical framework in evolutionary genetics that explains how duplicated genes accumulate deleterious mutations and lose functional capacity over time, distinguishing it from other gene duplication models by emphasizing the passive decay of genetic function in the absence of selective pressure.

41

Publications

3K

Citations

233

Authors

97

Institutions

Publications per year

2017–2026

17

Parents

Publications

41

A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration

Koichi Masuda, Yoichi Aota, Carol Muehleman et al. · Spine · 2005 · 723 citations

, , +11

Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice

Juthaporn Assawachananont, Michiko Mandai, Satoshi Okamoto et al. · Stem Cell Reports · 2014 · 355 citations · Full text

, , +13

TDP-43 Mediates Degeneration in a Novel<i>Drosophila</i>Model of Disease Caused by Mutations in VCP/p97

Gillian P. Ritson, Sara K. Custer, Brian D. Freibaum et al. · Journal of Neuroscience · 2010 · 269 citations · Full text

, , +17

<i>Dicer</i>Inactivation Leads to Progressive Functional and Structural Degeneration of the Mouse Retina

Devid Damiani, John Alexander, Jason ORourke et al. · Journal of Neuroscience · 2008 · 218 citations · Full text

, , +17

Conserved Functions of Yeast Genes Support the Duplication, Degeneration and Complementation Model for Gene Duplication

Ambro van Hoof · Genetics · 2005 · 109 citations · Full text

, , +16

1–5 of 41

Authors

233

  1. RJ
    Roel J. W. Hoogendoorn

    Amsterdam UMC Location Vrije Universiteit Amsterdam, Netherlands

    3 publications · 165 citations

    3

    h-index

  2. MN
    Marco N. Helder

    Amsterdam UMC Location Vrije Universiteit Amsterdam, Netherlands

    3 publications · 165 citations

    3

    h-index

  3. TH
    Theo H. Smit

    Amsterdam UMC Location Vrije Universiteit Amsterdam, Netherlands

    2 publications · 127 citations

    2

    h-index

  4. PW
    P. Wuisman

    Vrije Universiteit Amsterdam, Netherlands

    2 publications · 142 citations

    2

    h-index

  5. CY
    Chunshui Yu

    Tianjin Medical University General Hospital, China

    1 publications · 49 citations

    1

    h-index

1–5 of 233

Institutions

97

  1. Amsterdam UMC Location Vrije Universiteit Amsterdam

    Amsterdam, The Netherlands

    3 h-index

    6 publications

    234 citations

  2. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    14 publications

    2.5K citations

  3. University of Amsterdam

    Amsterdam, The Netherlands

    2 h-index

    2 publications

    127 citations

  4. Chinese University of Hong Kong

    Hong Kong, Hong Kong

    2 h-index

    15 publications

    695 citations

  5. Keio University

    Tokyo, Japan

    2 h-index

    10 publications

    481 citations

  6. University of Michigan

    Ann Arbor, United States

    1 h-index

    1 publications

    65 citations

  7. Southern Medical University

    Guangzhou, China

    1 h-index

    12 publications

    156 citations

  8. Imperial College London

    London, United Kingdom

    1 h-index

    1 publications

    15 citations

1–8 of 97

Venues

  1. Spine

    4 publications · 889 citations

    4

    h-index

  2. Journal of Neuroscience

    2 publications · 487 citations

    3

    h-index

  3. Experimental Eye Research

    3 publications · 149 citations

    3

    h-index

  4. European Spine Journal

    2 publications · 58 citations

    2

    h-index

  5. Journal of Orthopaedic Research®

    2 publications · 67 citations

    2

    h-index

1–5