Concepedia

Deadenylation-dependent Decay

Deadenylation-Dependent Decay is a molecular mechanism of mRNA degradation in which the removal of the poly(A) tail by deadenylases serves as the initial and rate-limiting step that triggers subsequent exonucleolytic decay of the transcript body.

177

Publications

21.7K

Citations

618

Authors

225

Institutions

Publications per year

2017–2026

28

Variants

Deadenylation-dependent Mrna Decay

Parents

Publications

177

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

Hao Du, Ya Zhao, Jinqiu He et al. · Nature Communications · 2016 · 1.5K citations · Full text

, , +17

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

Sergej Djuranović, Ali Nahvi, Rachel Green · Science · 2012 · 862 citations · Full text

, , +17

Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

Wi S. Lai, Ester Carballo, Julie R. Strum et al. · Molecular and Cellular Biology · 1999 · 728 citations · Full text

, , +16

The Transcription Factor Associated Ccr4 and Caf1 Proteins Are Components of the Major Cytoplasmic mRNA Deadenylase in Saccharomyces cerevisiae

Morgan Tucker, Marco Antonio Valencia-Sanchez, Robin R. Staples et al. · Cell · 2001 · 584 citations · Full text

, , +15

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

A B Shyu, Joel G. Belasco, Michael E. Greenberg · Genes & Development · 1991 · 545 citations · Full text

, , +17

1–5 of 177

Authors

618

  1. RP
    Roy Parker

    Howard Hughes Medical Institute, United States

    13 publications · 1.9K citations

    13

    h-index

  2. AS
    Ann‐Bin Shyu

    The University of Texas Health Science Center at Houston, United States

    12 publications · 2K citations

    12

    h-index

  3. EI
    Elisa Izaurralde

    Max Planck Institute for Developmental Biology, Germany

    7 publications · 873 citations

    7

    h-index

  4. JG
    Joel G. Belasco

    New York University, United States

    6 publications · 978 citations

    6

    h-index

  5. BS
    Bertrand Séraphin

    Centre National de la Recherche Scientifique, France

    6 publications · 434 citations

    6

    h-index

1–5 of 618

Institutions

225

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    17 h-index

    42 publications

    10.5K citations

  2. University of Arizona

    Tucson, United States

    15 h-index

    34 publications

    5.3K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    45 publications

    6.7K citations

  4. Max Planck Institute for Developmental Biology

    Tübingen, Germany

    9 h-index

    41 publications

    3.7K citations

  5. Rutgers, The State University of New Jersey

    New Brunswick, United States

    8 h-index

    22 publications

    2.4K citations

  6. The University of Tokyo

    Tokyo, Japan

    8 h-index

    40 publications

    3.2K citations

  7. Heidelberg University

    Heidelberg, Germany

    7 h-index

    29 publications

    1.8K citations

  8. University of Wisconsin–Madison

    Madison, United States

    6 h-index

    17 publications

    2.3K citations

1–8 of 225

Venues

  1. Molecular and Cellular Biology

    MCB · 34 publications · 5.1K citations

    29

    h-index

  2. Nucleic Acids Research

    21 publications · 1.3K citations

    21

    h-index

  3. Journal of Biological Chemistry

    JBC · 20 publications · 1.6K citations

    19

    h-index

  4. Molecular Cell

    9 publications · 1.9K citations

    9

    h-index

  5. The EMBO Journal

    8 publications · 1.3K citations

    8

    h-index

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