Concepedia

Ctcf-mediated Insulation

CTCF-Mediated Insulation is a genomic regulatory mechanism in which the chromatin architectural protein CTCF binds to specific DNA sequences to restrict enhancer-promoter interactions and establish topological boundaries, thereby insulating functionally distinct regulatory domains within the three-dimensional genome.

36

Publications

6.3K

Citations

279

Authors

122

Institutions

Publications per year

2017–2026

20

Parents

Publications

36

Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization

Elphège P. Nora, Anton Goloborodko, Anne-Laure Valton et al. · Cell · 2017 · 1.9K citations · Full text

, , +15

Cohesin mediates transcriptional insulation by CCCTC-binding factor

Kerstin S. Wendt, Keisuke Yoshida, Takehiko Itoh et al. · Nature · 2008 · 1.2K citations

, , +14

CTCF Tethers an Insulator to Subnuclear Sites, Suggesting Shared Insulator Mechanisms across Species

Timur Yusufzai, Hideaki Tagami, Yoshihiro Nakatani et al. · Molecular Cell · 2004 · 485 citations · Full text

, , +8

Nonlinear control of transcription through enhancer–promoter interactions

Jessica Zuin, Grégory Roth, Yinxiu Zhan et al. · Nature · 2022 · 443 citations · Full text

, , +17

Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation

Wenqiang Yu, Vasudeva Ginjala, Vinod Pant et al. · Nature Genetics · 2004 · 290 citations · Full text

, , +12

1–5 of 36

Authors

279

  1. GF
    Gary Felsenfeld

    National Institutes of Health, United States

    4 publications · 997 citations

    4

    h-index

  2. BG
    Benoit G. Bruneau

    Gladstone Institutes, United States

    3 publications · 1.9K citations

    3

    h-index

  3. EP
    Elphège P. Nora

    University of California, San Francisco, United States

    3 publications · 1.9K citations

    3

    h-index

  4. TX
    Tiaojiang Xiao

    National Institute of Diabetes and Digestive and Kidney Diseases, United States

    3 publications · 512 citations

    3

    h-index

  5. BB
    Bogdan Bintu

    Howard Hughes Medical Institute, United States

    2 publications · 210 citations

    2

    h-index

1–5 of 279

Institutions

122

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    19 publications

    6.7K citations

  2. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    4 h-index

    14 publications

    3.2K citations

  3. Max Delbrück Center

    Berlin, Germany

    4 h-index

    12 publications

    685 citations

  4. National Institutes of Health

    Bethesda, United States

    4 h-index

    7 publications

    2.1K citations

  5. Harvard University

    Cambridge, United States

    3 h-index

    8 publications

    500 citations

  6. Gladstone Institutes

    San Francisco, United States

    3 h-index

    8 publications

    5.7K citations

  7. University of California, San Francisco

    San Francisco, United States

    3 h-index

    3 publications

    1.9K citations

  8. New York University

    New York, United States

    3 h-index

    15 publications

    1.5K citations

1–8 of 122

Venues

  1. Nature Genetics

    5 publications · 695 citations

    5

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 4 publications · 53 citations

    4

    h-index

  3. Nature Communications

    3 publications · 225 citations

    3

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 214 citations

    3

    h-index

  5. Genes & Development

    3 publications · 333 citations

    3

    h-index

1–5