Concepedia

Conformational Selection Modeling

Conformational Selection Modeling is a theoretical framework in allosteric regulation modeling that posits ligand binding selects and stabilizes pre-existing protein conformations from an equilibrium ensemble, thereby shifting the conformational distribution without inducing structural changes de novo.

93

Publications

5K

Citations

422

Authors

189

Institutions

Publications per year

2017–2026

32

Parents

Publications

93

Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

Oliver F. Lange, Nils‐Alexander Lakomek, Christophe Farès et al. · Science · 2008 · 1.1K citations · Full text

, , +17

Perturbation-Response Scanning Reveals Ligand Entry-Exit Mechanisms of Ferric Binding Protein

Canan Atılgan, Ali Rana Atılgan · PLoS Computational Biology · 2009 · 249 citations · Full text

, , +17

Conformational selection and induced fit mechanism underlie specificity in noncovalent interactions with ubiquitin

Tomasz Włodarski, Bojan Žagrović · Proceedings of the National Academy of Sciences · 2009 · 197 citations · Full text

, , +17

Markov State Model Reveals Folding and Functional Dynamics in Ultra-Long MD Trajectories

Thomas J. Lane, Gregory R. Bowman, Kyle A. Beauchamp et al. · Journal of the American Chemical Society · 2011 · 177 citations · Full text

, , +17

Differential Transition-State Stabilization in Enzyme Catalysis:  Quantum Chemical Analysis of Interactions in the Chorismate Mutase Reaction and Prediction of the Optimal Catalytic Field

Borys Szefczyk, Adrian J. Mulholland, Kara E. Ranaghan et al. · Journal of the American Chemical Society · 2004 · 112 citations

, , +17

1–5 of 93

Authors

422

  1. JJ
    Jesús Jiménez‐Barbero

    Centro de Investigaciones Biológicas Margarita Salas, Spain

    5 publications · 274 citations

    5

    h-index

  2. VA
    Vincent A. Voelz

    Temple University, United States

    3 publications · 227 citations

    3

    h-index

  3. ÁC
    Ángeles Canales

    Centro de Investigaciones Biológicas Margarita Salas, Spain

    3 publications · 171 citations

    3

    h-index

  4. BL
    Bert L. de Groot

    Max Planck Institute for Biophysical Chemistry, Germany

    3 publications · 1.2K citations

    3

    h-index

  5. LD
    Lucie Delemotte

    KTH Royal Institute of Technology, Sweden

    2 publications · 83 citations

    2

    h-index

1–5 of 422

Institutions

189

  1. University of Washington

    Seattle, United States

    5 h-index

    20 publications

    1.1K citations

  2. Vanderbilt University

    Nashville, United States

    4 h-index

    19 publications

    11K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    15 publications

    531 citations

  4. Stanford University

    Stanford, United States

    4 h-index

    14 publications

    1.2K citations

  5. Centro de Investigaciones Biológicas Margarita Salas

    Madrid, Spain

    4 h-index

    16 publications

    911 citations

  6. KTH Royal Institute of Technology

    Stockholm, Sweden

    4 h-index

    20 publications

    1.6K citations

  7. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    9 publications

    343 citations

  8. University of California San Diego

    San Diego, United States

    3 h-index

    6 publications

    185 citations

1–8 of 189

Venues

  1. Journal of the American Chemical Society

    JACS · 9 publications · 695 citations

    9

    h-index

  2. Proteins Structure Function and Bioinformatics

    6 publications · 150 citations

    6

    h-index

  3. PLoS Computational Biology

    6 publications · 578 citations

    6

    h-index

  4. Journal of Biological Chemistry

    JBC · 6 publications · 248 citations

    6

    h-index

  5. Scientific Reports

    5 publications · 79 citations

    5

    h-index

1–5