Concepedia

Conformational Ensemble Engineering

Conformational Ensemble Engineering is a methodological framework in allosteric protein engineering that enables the systematic design and manipulation of the distribution of protein conformational states to achieve desired functional outcomes through targeted perturbations of dynamic structural equilibria.

4

Publications

135

Citations

14

Authors

8

Institutions

Publications per year

2017–2026

3

Parents

Publications

4

Conformational Re‐engineering of Porphyrins as Receptors with Switchable N−H⋅⋅⋅X‐Type Binding Modes

Karolis Norvaiša, Keith J. Flanagan, Dáire Gibbons et al. · Angewandte Chemie International Edition · 2019 · 42 citations · Full text

, , +17

APE-Gen: A Fast Method for Generating Ensembles of Bound Peptide-MHC Conformations

Jayvee R. Abella, Dinler A. Antunes, Cecilia Clementi et al. · Molecules · 2019 · 41 citations · Full text

, , +17

A Rapid, Ensemble and Free Energy Based Method for Engineering Protein Stabilities

Athi N. Naganathan · The Journal of Physical Chemistry B · 2013 · 30 citations

, , +17

Unveiling the “invisible” druggable conformations of GDP-bound inactive Ras

Dan Liu, Yunyun Mao, Xue Gu et al. · Proceedings of the National Academy of Sciences · 2021 · 22 citations · Full text

, , +17

1–4 of 4

Authors

14

  1. JR
    Jayvee R. Abella

    Rice University, United States

    1 publications · 41 citations

    1

    h-index

  2. DL
    Dong Long

    National High Magnetic Field Laboratory, United States

    1 publications · 22 citations

    1

    h-index

  3. XG
    Xue Gu

    Hefei National Center for Physical Sciences at Nanoscale, China

    1 publications · 22 citations

    1

    h-index

  4. YM
    Yunyun Mao

    Hefei National Center for Physical Sciences at Nanoscale, China

    1 publications · 22 citations

    1

    h-index

  5. MO
    Mathias O. Senge

    Trinity College Dublin, Ireland

    1 publications · 42 citations

    1

    h-index

1–5 of 14

Institutions

8

  1. Indian Institute of Technology Madras

    Chennai, India

    1 h-index

    1 publications

    30 citations

  2. Hefei National Center for Physical Sciences at Nanoscale

    Hefei, China

    1 h-index

    5 publications

    110 citations

  3. University of Science and Technology of China

    Hefei, China

    1 h-index

    5 publications

    110 citations

  4. Trinity College Dublin

    Dublin, Ireland

    1 h-index

    4 publications

    168 citations

  5. Rice University

    Houston, United States

    1 h-index

    4 publications

    164 citations

  6. Institute for Advanced Study

    Berlin, Germany

    1 h-index

    1 publications

    42 citations

  7. Technical University of Munich

    Munich, Germany

    1 h-index

    1 publications

    42 citations

  8. Center for Theoretical Biological Physics

    Houston, United States

    1 h-index

    1 publications

    41 citations

1–8 of 8

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 22 citations

    1

    h-index

  2. Molecules

    1 publications · 41 citations

    1

    h-index

  3. Angewandte Chemie International Edition

    1 publications · 42 citations

    1

    h-index

  4. The Journal of Physical Chemistry B

    1 publications · 30 citations

    1

    h-index

1–4