Concepedia

Complexin-mediated Priming

Complexin-Mediated Priming is a molecular mechanism in synaptic vesicle exocytosis that belongs to the class of vesicle priming processes, distinguished by the essential regulatory role of complexin proteins in stabilizing the SNARE complex in a fusion-competent state prior to calcium-triggered neurotransmitter release.

13

Publications

1.4K

Citations

57

Authors

24

Institutions

Publications per year

2017–2026

3

Parents

Publications

13

A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth

Sarah Huntwork, J. Troy Littleton · Nature Neuroscience · 2007 · 299 citations

, , +16

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

Xiaoyu Yang, Shen Wang, Yi Sheng et al. · Nature Structural & Molecular Biology · 2015 · 194 citations · Full text

, , +16

Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs

S.L. Eastwood, Paul J. Harrison · Molecular Psychiatry · 2000 · 172 citations

, , +17

Complexin Maintains Vesicles in the Primed State in C. elegans

Robert J. Hobson, Qiang Liu, Shigeki Watanabe et al. · Current Biology · 2011 · 129 citations · Full text

, , +13

Deconstructing complexin function in activating and clamping Ca <sup>2+</sup> -triggered exocytosis by comparing knockout and knockdown phenotypes

Xiaofei Yang, Peng Cao, Thomas C. Südhof · Proceedings of the National Academy of Sciences · 2013 · 99 citations · Full text

, , +17

1–5 of 13

Authors

57

  1. KR
    Kerstin Reim

    Max Planck Institute of Experimental Medicine, Germany

    3 publications · 196 citations

    3

    h-index

  2. NB
    Nils Brose

    Max Planck Institute of Experimental Medicine, Germany

    3 publications · 196 citations

    3

    h-index

  3. JR
    Josep Rizo

    The University of Texas Southwestern Medical Center, United States

    2 publications · 280 citations

    2

    h-index

  4. JT
    J. Troy Littleton

    Massachusetts Institute of Technology, United States

    2 publications · 380 citations

    2

    h-index

  5. XY
    Xiaofei Yang

    Howard Hughes Medical Institute, United States

    2 publications · 197 citations

    2

    h-index

1–5 of 57

Institutions

24

  1. Max Planck Institute of Experimental Medicine

    Göttingen, Germany

    3 h-index

    11 publications

    688 citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    8 publications

    911 citations

  3. Stanford University

    Stanford, United States

    2 h-index

    5 publications

    493 citations

  4. The University of Texas Southwestern Medical Center

    Dallas, United States

    2 h-index

    6 publications

    624 citations

  5. Max Planck Institute for Biophysical Chemistry

    Göttingen, Germany

    2 h-index

    6 publications

    432 citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    5 publications

    841 citations

  7. Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103

    Göttingen, Germany

    2 h-index

    6 publications

    360 citations

  8. Palo Alto University

    Palo Alto, United States

    1 h-index

    1 publications

    98 citations

1–8 of 24

Venues

  1. eLife

    2 publications · 108 citations

    2

    h-index

  2. Journal of Neuroscience

    2 publications · 168 citations

    2

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 175 citations

    2

    h-index

  4. Molecular and Cellular Neuroscience

    MCN · 2 publications · 112 citations

    2

    h-index

  5. Nature Structural & Molecular Biology

    1 publications · 194 citations

    1

    h-index

1–5