Concepedia

Cofactor-dependent Stability

Cofactor-Dependent Stability is an enzyme stability construct that refers to the extent to which an enzyme's structural integrity and functional activity are maintained in the presence of its required cofactor, distinguishing it from intrinsic or ligand-independent stability mechanisms.

7

Publications

273

Citations

46

Authors

16

Institutions

Publications per year

2017–2026

3

Parents

Publications

7

Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding

Rebecca Beveridge, Lukasz G. Migas, K.A.P. Payne et al. · Nature Communications · 2016 · 77 citations · Full text

, , +17

Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction

Feng Xu, Birgit Kosjek, Fabien L. Cabirol et al. · Angewandte Chemie International Edition · 2018 · 59 citations

, , +17

Ubiquitination of Alzheimer's-related tau protein affects liquid-liquid phase separation in a site- and cofactor-dependent manner

Francesca Parolini, Roberto Tira, Carlo Giorgio Barracchia et al. · International Journal of Biological Macromolecules · 2022 · 41 citations

, , +16

Differential Cofactor Requirements for Histone Eviction from Two Nucleosomes at the Yeast <i>PHO84</i> Promoter Are Determined by Intrinsic Nucleosome Stability

Christian J. Wippo, Bojana Silic Krstulovic, Franziska Ertel et al. · Molecular and Cellular Biology · 2009 · 40 citations · Full text

, , +16

Identification of Residues Contributing to A2 Domain-dependent Structural Stability in Factor VIII and Factor VIIIa

Hironao Wakabayashi, Philip J. Fay · Journal of Biological Chemistry · 2008 · 27 citations · Full text

, , +17

1–5 of 7

Authors

46

  1. OE
    Olga Esakova

    Pennsylvania State University, United States

    1 publications · 19 citations

    1

    h-index

  2. DG
    David G. VanderVelde

    California Institute of Technology, United States

    1 publications · 10 citations

    1

    h-index

  3. DB
    Dorothea Blaschke

    Ludwig-Maximilians-Universität München, Germany

    1 publications · 40 citations

    1

    h-index

  4. LG
    Lukasz G. Migas

    Vanderbilt University, United States

    1 publications · 77 citations

    1

    h-index

  5. SB
    Slobodan Barbarić

    University of Zagreb, Croatia

    1 publications · 40 citations

    1

    h-index

1–5 of 46

Institutions

16

  1. Dana-Farber Cancer Institute

    Boston, United States

    1 h-index

    1 publications

    40 citations

  2. Southern California Earthquake Center

    Los Angeles, United States

    1 h-index

    1 publications

    10 citations

  3. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    1 h-index

    7 publications

    413 citations

  4. Jet Propulsion Laboratory

    Pasadena, United States

    1 h-index

    2 publications

    20 citations

  5. University of Zagreb

    Zagreb, Croatia

    1 h-index

    3 publications

    120 citations

  6. University of Rochester

    Rochester, United States

    1 h-index

    2 publications

    54 citations

  7. Codexis (United States)

    Redwood City, United States

    1 h-index

    6 publications

    354 citations

  8. Oberlin College

    Oberlin, United States

    1 h-index

    1 publications

    10 citations

1–8 of 16

Venues

  1. 1

    h-index

  2. Life Sciences

    1 publications · 19 citations

    1

    h-index

  3. Journal of Biological Chemistry

    JBC · 1 publications · 27 citations

    1

    h-index

  4. Molecular and Cellular Biology

    MCB · 1 publications · 40 citations

    1

    h-index

  5. Nature Communications

    1 publications · 77 citations

    1

    h-index

1–5