Concepedia

Cofactor Dynamics

Cofactor Dynamics is a theoretical framework within enzymology that characterizes the conformational and functional interplay between enzymes and their essential non-protein cofactors during catalytic cycles, distinguishing itself by explicitly modeling the temporal and allosteric coordination underlying cofactor-dependent catalysis.

27

Publications

3.6K

Citations

165

Authors

63

Institutions

Publications per year

2017–2026

10

Parents

Publications

27

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

Yongfeng Shang, Xiao Hu, James DiRenzo et al. · Cell · 2000 · 1.7K citations · Full text

, , +14

Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase

Koen H. G. Verschueren, F.R. Seljee, H.J. Rozeboom et al. · Nature · 1993 · 471 citations · Full text

, , +16

Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor

I.A. Mirza, Brahm J. Yachnin, Shaozhao Wang et al. · Journal of the American Chemical Society · 2009 · 173 citations · Full text

, , +17

Single-molecule analysis of steroid receptor and cofactor action in living cells

Ville Paakinaho, Diego M. Presman, David A. Ball et al. · Nature Communications · 2017 · 153 citations · Full text

, , +17

The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis

Cristofer Enroth, Halina Y. Neujahr, G. Schneider et al. · Structure · 1998 · 150 citations · Full text

, , +15

1–5 of 27

Authors

165

  1. JH
    Joachim Heberle

    Freie Universität Berlin, Germany

    3 publications · 209 citations

    3

    h-index

  2. UA
    Ulf‐Peter Apfel

    Ruhr University Bochum, Germany

    2 publications · 122 citations

    2

    h-index

  3. SP
    Stephen P. Cramer

    University of California, Davis, United States

    2 publications · 75 citations

    2

    h-index

  4. ST
    Sven T. Stripp

    Freie Universität Berlin, Germany

    2 publications · 122 citations

    2

    h-index

  5. SM
    Stefan Mebs

    Freie Universität Berlin, Germany

    2 publications · 122 citations

    2

    h-index

1–5 of 165

Institutions

63

  1. Lawrence Berkeley National Laboratory

    Berkeley, United States

    3 h-index

    8 publications

    238 citations

  2. University of Groningen

    Groningen, The Netherlands

    3 h-index

    15 publications

    2.9K citations

  3. Freie Universität Berlin

    Berlin, Germany

    2 h-index

    11 publications

    664 citations

  4. Stockholm University

    Stockholm, Sweden

    2 h-index

    5 publications

    288 citations

  5. Ruhr University Bochum

    Bochum, Germany

    2 h-index

    9 publications

    528 citations

  6. Karolinska Institutet

    Stockholm, Sweden

    2 h-index

    8 publications

    640 citations

  7. University of California, Davis

    Davis, United States

    2 h-index

    8 publications

    300 citations

  8. University of California, Berkeley

    Berkeley, United States

    2 h-index

    8 publications

    176 citations

1–8 of 63

Venues

  1. Biochemistry

    3 publications · 62 citations

    3

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 95 citations

    2

    h-index

  3. ACS Catalysis

    2 publications · 105 citations

    2

    h-index

  4. Journal of the American Chemical Society

    JACS · 2 publications · 218 citations

    2

    h-index

  5. Journal of Molecular Biology

    JMB · 2 publications · 112 citations

    2

    h-index

1–5