Concepedia

Codon-based Library Design

Codon-Based Library Design is a targeted mutagenesis strategy in molecular biology that utilizes codon-level optimization to construct gene libraries by systematically introducing nucleotide variations at defined positions, thereby enabling precise diversification of protein sequences while minimizing non-synonymous or frameshift mutations.

19

Publications

729

Citations

73

Authors

28

Institutions

Publications per year

2017–2026

3

Parents

Publications

19

Expanding the genetic code: selection of efficient suppressors of four-base codons and identification of “shifty” four-base codons with a library approach in Escherichia coli11Edited by M. Gottesman

Thomas J. Magliery, J. Christopher Anderson · Journal of Molecular Biology · 2001 · 134 citations

, , +10

Combinatorial codon scrambling enables scalable gene synthesis and amplification of repetitive proteins

Nicholas Tang, Ashutosh Chilkoti · Nature Materials · 2016 · 80 citations

, , +14

Automated design of degenerate codon libraries

Marco Mena, Patrick S. Daugherty · Protein Engineering Design and Selection · 2005 · 71 citations · Full text

, , +17

SwiftLib: rapid degenerate-codon-library optimization through dynamic programming

Timothy M. Jacobs, Hayretin Yumerefendi, Brian Kuhlman et al. · Nucleic Acids Research · 2014 · 69 citations · Full text

, , +17

Revealing determinants of translation efficiency via whole-gene codon randomization and machine learning

Thijs Nieuwkoop, Barbara R. Terlouw, Katherine G. Stevens et al. · Nucleic Acids Research · 2023 · 61 citations · Full text

, , +15

1–5 of 19

Authors

73

  1. GR
    Geeta Ram

    New York University, United States

    2 publications · 23 citations

    2

    h-index

  2. AR
    Alka Rao

    Indian Institute of Chemical Technology, India

    2 publications · 23 citations

    2

    h-index

  3. AR
    Anand Ranganathan

    IBM (United States), United States

    2 publications · 23 citations

    2

    h-index

  4. PG
    Paul Gaytán

    Universidad Nacional Autónoma de México, Mexico

    2 publications · 27 citations

    2

    h-index

  5. NS
    Nina Schürmann

    Heidelberg University, Germany

    1 publications · 42 citations

    1

    h-index

1–5 of 73

Institutions

28

  1. International Centre for Genetic Engineering and Biotechnology

    New Delhi, India

    2 h-index

    9 publications

    105 citations

  2. German Center for Infection Research

    Braunschweig, Germany

    1 h-index

    1 publications

    42 citations

  3. Scripps Research Institute

    San Diego, United States

    1 h-index

    3 publications

    402 citations

  4. Universidad Americana de Morelos

    Cuernavaca, Mexico

    1 h-index

    1 publications

    12 citations

  5. University of California, Berkeley

    Berkeley, United States

    1 h-index

    1 publications

    134 citations

  6. National University of Singapore

    Singapore, Singapore

    1 h-index

    2 publications

    48 citations

  7. Aston University

    Birmingham, United Kingdom

    1 h-index

    1 publications

    25 citations

  8. Institute of Genomics and Integrative Biology

    Delhi, India

    1 h-index

    3 publications

    30 citations

1–8 of 28

Venues

  1. Nucleic Acids Research

    4 publications · 174 citations

    4

    h-index

  2. ACS Synthetic Biology

    4 publications · 98 citations

    4

    h-index

  3. Nature Materials

    1 publications · 80 citations

    1

    h-index

  4. BioTechniques

    1 publications · 12 citations

    1

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 1 publications · 71 citations

    1

    h-index

1–5