Concepedia

Cic-rearranged Sarcoma

CIC-Rearranged Sarcoma is a distinct subtype of undifferentiated round cell sarcoma characterized by recurrent genetic rearrangements involving the *CIC* gene, most commonly fusing it with *DUX4*, and distinguished by its aggressive clinical behavior, specific immunohistochemical profile, and molecular signature within the family of Ewing-like sarcomas.

55

Publications

4.7K

Citations

441

Authors

171

Institutions

Publications per year

2017–2026

34

Parents

Publications

55

Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation

Miho Kawamura-Saito, Yukari Yamazaki, Keiko Kaneko et al. · Human Molecular Genetics · 2006 · 458 citations

, , +16

Sarcomas With CIC-rearrangements Are a Distinct Pathologic Entity With Aggressive Outcome

Cristina R. Antonescu, Adepitan A. Owosho, Lei Zhang et al. · The American Journal of Surgical Pathology · 2017 · 398 citations

, , +17

High prevalence of <i>CIC</i> fusion with double‐homeobox (DUX4) transcription factors in <i>EWSR1</i> ‐negative undifferentiated small blue round cell sarcomas

Antoîne Italiano, Yun Shao Sung, Lei Zhang et al. · Genes Chromosomes and Cancer · 2011 · 357 citations · Full text

, , +16

Transcriptomic definition of molecular subgroups of small round cell sarcomas

Sarah Watson, Virginie Perrin, Delphine Guillemot et al. · The Journal of Pathology · 2018 · 330 citations

, , +17

Distinct transcriptional signature and immunoprofile of <i>CIC‐DUX4</i> fusion–positive round cell tumors compared to <i>EWSR1</i> ‐rearranged ewing sarcomas: Further evidence toward distinct pathologic entities

Katja Specht, Yun‐Shao Sung, Lei Zhang et al. · Genes Chromosomes and Cancer · 2014 · 244 citations

, , +17

1–5 of 55

Authors

441

  1. CR
    Cristina R. Antonescu

    Memorial Sloan Kettering Cancer Center, United States

    11 publications · 1.7K citations

    11

    h-index

  2. CD
    Christopher D.�M. Fletcher

    Brigham and Women's Hospital, United States

    6 publications · 1.1K citations

    6

    h-index

  3. AY
    Akihiko Yoshida

    Tokyo National Hospital, Japan

    5 publications · 359 citations

    5

    h-index

  4. FT
    Franck Tirode

    Inserm, France

    5 publications · 653 citations

    5

    h-index

  5. WD
    William D. Tap

    Memorial Sloan Kettering Cancer Center, United States

    5 publications · 738 citations

    5

    h-index

1–5 of 441

Institutions

171

  1. Memorial Sloan Kettering Cancer Center

    New York, United States

    12 h-index

    41 publications

    4.9K citations

  2. Brigham and Women's Hospital

    Boston, United States

    8 h-index

    15 publications

    2K citations

  3. Institut Bergonié

    Bordeaux, France

    7 h-index

    13 publications

    2.2K citations

  4. Harvard University

    Cambridge, United States

    7 h-index

    16 publications

    1.9K citations

  5. Institut Curie

    Paris, France

    5 h-index

    18 publications

    3.8K citations

  6. Inserm

    Paris, France

    4 h-index

    16 publications

    2.8K citations

  7. Istituto Ortopedico Rizzoli

    Bologna, Italy

    4 h-index

    44 publications

    1.9K citations

  8. Centre Léon Bérard

    Lyon, France

    4 h-index

    14 publications

    1.3K citations

1–8 of 171

Venues

  1. The American Journal of Surgical Pathology

    7 publications · 1.3K citations

    7

    h-index

  2. Genes Chromosomes and Cancer

    6 publications · 823 citations

    6

    h-index

  3. Modern Pathology

    4 publications · 360 citations

    4

    h-index

  4. Pathology - Research and Practice

    4 publications · 59 citations

    4

    h-index

  5. Journal of Cutaneous Pathology

    JCP · 2 publications · 63 citations

    2

    h-index

1–5