Concepedia

Checkpoint Blockade Modulation

Checkpoint Blockade Modulation is a therapeutic strategy in autoimmune disease immunotherapy that involves the precise regulation of immune checkpoint pathways to restore self-tolerance by selectively inhibiting or enhancing co-signaling receptors that control T-cell activation and immune homeostasis.

122

Publications

13.2K

Citations

1.2K

Authors

345

Institutions

Publications per year

2017–2026

111

Parents

Publications

122

PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer

Andrea Cercek, Melissa Lumish, Jenna Sinopoli et al. · New England Journal of Medicine · 2022 · 1.5K citations · Full text

, , +17

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

Qing Zhang, Jiacheng Bi, Xiaodong Zheng et al. · Nature Immunology · 2018 · 1.1K citations

, , +16

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

Wanqiang Sheng, Martin W. LaFleur, Thao H. Nguyen et al. · Cell · 2018 · 679 citations

, , +14

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice R. Gurbatri, Ioana Lia, Rosa L. Vincent et al. · Science Translational Medicine · 2020 · 596 citations · Full text

, , +17

Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice

Wenwen Yue, Liang Chen, Luodan Yu et al. · Nature Communications · 2019 · 594 citations · Full text

, , +17

1–5 of 122

Authors

1.2K

  1. AM
    Avni M. Desai

    Memorial Sloan Kettering Cancer Center, United States

    3 publications · 1.6K citations

    3

    h-index

  2. MR
    Martin R. Weiser

    Memorial Sloan Kettering Cancer Center, United States

    3 publications · 1.6K citations

    3

    h-index

  3. ZK
    Zsofia K. Stadler

    Memorial Sloan Kettering Cancer Center, United States

    3 publications · 1.6K citations

    3

    h-index

  4. JS
    Jinru Shia

    Memorial Sloan Kettering Cancer Center, United States

    3 publications · 1.6K citations

    3

    h-index

  5. NH
    Neil H. Segal

    Memorial Sloan Kettering Cancer Center, United States

    3 publications · 1.6K citations

    3

    h-index

1–5 of 1.2K

Institutions

345

  1. Memorial Sloan Kettering Cancer Center

    New York, United States

    8 h-index

    98 publications

    45.1K citations

  2. Huazhong University of Science and Technology

    Wuhan, China

    6 h-index

    55 publications

    7.4K citations

  3. Brigham and Women's Hospital

    Boston, United States

    5 h-index

    10 publications

    1.8K citations

  4. Fudan University

    Shanghai, China

    4 h-index

    17 publications

    877 citations

  5. The University of Texas MD Anderson Cancer Center

    Houston, United States

    4 h-index

    11 publications

    736 citations

  6. Dana-Farber Cancer Institute

    Boston, United States

    4 h-index

    9 publications

    2.8K citations

  7. Shanghai Jiao Tong University

    Shanghai, China

    4 h-index

    12 publications

    755 citations

  8. Harvard University

    Cambridge, United States

    4 h-index

    27 publications

    8.4K citations

1–8 of 345

Venues

  1. Nature Communications

    10 publications · 1.8K citations

    11

    h-index

  2. Cancer Immunology Immunotherapy

    4 publications · 490 citations

    4

    h-index

  3. JCI Insight

    2 publications · 172 citations

    3

    h-index

  4. Journal of Clinical Investigation

    JCI · 3 publications · 164 citations

    3

    h-index

  5. Cancer Research

    2 publications · 63 citations

    3

    h-index

1–5