Concepedia

Chain Shuffling

Chain Shuffling is a recombinant antibody engineering technique that involves the pairwise recombination of heavy and light chain variable genes from different B-cell lineages to generate novel antibody variants with enhanced affinity or specificity during in vitro affinity maturation.

39

Publications

2K

Citations

244

Authors

99

Institutions

Publications per year

2017–2026

8

Parents

Publications

39

By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling

James D. Marks, Andrew D. Griffiths, Magnus Malmqvist et al. · Nature Biotechnology · 1992 · 406 citations

, , +14

Exceptionally Potent Cross-Reactive Neutralization of Nipah and Hendra Viruses by a Human Monoclonal Antibody

Zhongyu Zhu, Katharine N. Bossart, Kimberly A. Bishop et al. · The Journal of Infectious Diseases · 2008 · 182 citations · Full text

, , +17

Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries.

Angray S. Kang, Terri Jones, Dennis R. Burton · Proceedings of the National Academy of Sciences · 1991 · 143 citations

, , +17

Patchy Particle Model for Vitrimers

Frank Smallenburg, Ludwik Leibler, Francesco Sciortino · Physical Review Letters · 2013 · 120 citations

, , +17

Shuffled antibody libraries created by in vivo homologous recombination and yeast surface display

J. S. Swers · Nucleic Acids Research · 2004 · 100 citations · Full text

, , +17

1–5 of 39

Authors

244

  1. RO
    Richard O’Kennedy

    Dublin City University, Ireland

    3 publications · 122 citations

    3

    h-index

  2. GW
    Greg Winter

    MRC Laboratory of Molecular Biology, United Kingdom

    2 publications · 435 citations

    2

    h-index

  3. FR
    Florian Rüker

    BOKU University, Austria

    2 publications · 43 citations

    2

    h-index

  4. HS
    Holger Spiegel

    Fraunhofer Institute for Molecular Biology and Applied Ecology, Germany

    2 publications · 27 citations

    2

    h-index

  5. MY
    Montarop Yamabhai

    Suranaree University of Technology, Thailand

    2 publications · 43 citations

    2

    h-index

1–5 of 244

Institutions

99

  1. Dublin City University

    Dublin, Ireland

    3 h-index

    6 publications

    143 citations

  2. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    3 h-index

    10 publications

    2.6K citations

  3. BOKU University

    Vienna, Austria

    2 h-index

    3 publications

    59 citations

  4. Fraunhofer Institute for Molecular Biology and Applied Ecology

    Schmallenberg, Germany

    2 h-index

    16 publications

    207 citations

  5. Scripps Research Institute

    San Diego, United States

    2 h-index

    9 publications

    915 citations

  6. Suranaree University of Technology

    Nakhon Ratchasima, Thailand

    2 h-index

    4 publications

    86 citations

  7. Science Applications International Corporation (United States)

    McLean, United States

    1 h-index

    1 publications

    182 citations

  8. Universidade Federal do Paraná

    Curitiba, Brazil

    1 h-index

    2 publications

    80 citations

1–8 of 99

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 234 citations

    3

    h-index

  2. The Journal of Biochemistry

    JB · 2 publications · 39 citations

    2

    h-index

  3. Analytical Biochemistry

    2 publications · 48 citations

    2

    h-index

  4. PubMed

    Repository · 2 publications · 81 citations

    2

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 1 publications · 15 citations

    1

    h-index

1–5