Concepedia

Centrosome Overduplication

Centrosome Overduplication is a biological phenomenon characterized by the abnormal replication of centrosomes beyond the normal once-per-cell-cycle limit, leading to the presence of more than two centrosomes in a cell, which can contribute to genomic instability and tumorigenesis.

126

Publications

10.5K

Citations

789

Authors

277

Institutions

Publications per year

2017–2026

22

Parents

Publications

126

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

Hongyi Zhou, Jian Kuang, Ling Zhong et al. · Nature Genetics · 1998 · 1.3K citations

, , +12

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

Kei Nakayama · The EMBO Journal · 2000 · 710 citations · Full text

, , +16

Network modeling links breast cancer susceptibility and centrosome dysfunction

Miguel Ángel Pujana, Jing-Dong Han, Lea M. Starita et al. · Nature Genetics · 2007 · 634 citations

, , +14

The C. elegans zyg-1 Gene Encodes a Regulator of Centrosome Duplication with Distinct Maternal and Paternal Roles in the Embryo

Kevin O‘Connell, Cathy Caron, Kevin R Kopish et al. · Cell · 2001 · 313 citations · Full text

, , +14

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

Onur Cizmecioglu, Marc Arnold, Ramona Bahtz et al. · The Journal of Cell Biology · 2010 · 287 citations · Full text

, , +16

1–5 of 126

Authors

789

  1. SD
    Stefan Duensing

    Heidelberg University, Germany

    10 publications · 437 citations

    10

    h-index

  2. AD
    Anette Duensing

    UPMC Hillman Cancer Center, United States

    7 publications · 306 citations

    7

    h-index

  3. NK
    Nina Korzeniewski

    University Hospital Heidelberg, Germany

    6 publications · 242 citations

    6

    h-index

  4. KM
    Karl Münger

    Harvard University, United States

    4 publications · 163 citations

    4

    h-index

  5. EA
    Erich A. Nigg

    Max Planck Institute of Biochemistry, Germany

    4 publications · 523 citations

    4

    h-index

1–5 of 789

Institutions

277

  1. Heidelberg University

    Heidelberg, Germany

    12 h-index

    66 publications

    6.2K citations

  2. UPMC Hillman Cancer Center

    Pittsburgh, United States

    9 h-index

    35 publications

    1.5K citations

  3. German Cancer Research Center

    Heidelberg, Germany

    9 h-index

    47 publications

    5K citations

  4. University of Pittsburgh

    Pittsburgh, United States

    7 h-index

    15 publications

    741 citations

  5. Inserm

    Paris, France

    6 h-index

    43 publications

    1.7K citations

  6. University Hospital Heidelberg

    Heidelberg, Germany

    5 h-index

    17 publications

    595 citations

  7. Brigham and Women's Hospital

    Boston, United States

    5 h-index

    11 publications

    1.6K citations

  8. Harvard University

    Cambridge, United States

    5 h-index

    25 publications

    11.1K citations

1–8 of 277

Venues

  1. Oncogene

    16 publications · 1.2K citations

    15

    h-index

  2. Journal of Cell Science

    8 publications · 682 citations

    8

    h-index

  3. Cell Cycle

    6 publications · 182 citations

    6

    h-index

  4. The Journal of Cell Biology

    JCB · 5 publications · 812 citations

    5

    h-index

  5. Cancer Research

    5 publications · 220 citations

    5

    h-index

1–5