Cell-state Heterogeneity

Cell-State Heterogeneity is a biological phenomenon characterized by the presence of distinct functional or molecular states among individual cells within a seemingly homogeneous population, arising from stochastic gene expression, microenvironmental influences, or regulatory dynamics that differentiate cellular phenotypes in single-cell systems.

473

Publications

54.8K

Citations

2.4K

Authors

738

Institutions

Publications per year

2017–2026

173

Variants

Cell State HeterogeneityCellular Heterogeneity

Parents

Single-cell Systems Biology

Children

Bistable Cell StatesCancer Cell-state HeterogeneityCell-cycle HeterogeneityCell-state PlasticityCell-state SignaturesCellular Reprogramming StatesClonal State DiversityDevelopmental Cell-state DynamicsDifferentiation HeterogeneityDrug-tolerant Persister States

Publications

473

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Cole Trapnell, Davide Cacchiarelli, Jonna Grimsby et al. · Nature Biotechnology · 2014 · 7.8K citations · Full text

Life Sciences, Cell Biology, Developmental Biology +16

Conserved cell types with divergent features in human versus mouse cortex

Rebecca D. Hodge, Trygve E. Bakken, Jeremy A. Miller et al. · Nature · 2019 · 2K citations

Life Sciences, Neurobiology, Neuroscience +16

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

Piyush B. Gupta, Christine M. Fillmore, Guozhi Jiang et al. · Cell · 2011 · 1.5K citations · Full text

Engineering, Cancer Biology, Cell Biology +16

Molecular Definition of Breast Tumor Heterogeneity

Michail Shipitsin, Lauren L. Campbell, Pedram Argani et al. · Cancer Cell · 2007 · 1.4K citations · Full text

Medicine, Molecular Biology, Oncology +14

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

Takahiro Masuda, Roman Sankowski, Ori Staszewski et al. · Nature · 2019 · 1.4K citations · Full text

Life Sciences, Cell Biology, Neuroscience +16

1–5 of 473

Authors

2.4K

LF
Lani F. Wu
University of California, San Francisco, United States
5 publications · 1.6K citations
5
h-index
SJ
Steven J. Altschuler
University of California, San Francisco, United States
5 publications · 1.6K citations
5
h-index
QN
Qing Nie
University of California, Irvine, United States
4 publications · 271 citations
4
h-index
SH
Sui Huang
Institute for Systems Biology, United States
4 publications · 478 citations
4
h-index
NV
Nikos V. Mantzaris
Rice University, United States
4 publications · 145 citations
4
h-index

1–5 of 2.4K

Institutions

738

1–8 of 738

Venues

Journal of Theoretical Biology
18 publications · 755 citations
17
h-index
Nature
14 publications · 7.8K citations
13
h-index
PubMed
Repository · 17 publications · 477 citations
13
h-index
PLoS Computational Biology
12 publications · 642 citations
12
h-index
Biophysical Journal
11 publications · 672 citations
11
h-index

1–5