Concepedia

Catalytic Triads

Catalytic Triad is a functional unit within enzyme active sites, consisting of three coordinated amino acid residues that act in concert to enhance catalytic efficiency through concerted acid-base and nucleophilic mechanisms in the context of acid-base catalysis.

117

Publications

8.2K

Citations

541

Authors

244

Institutions

Publications per year

2017–2026

26

Parents

Publications

117

The <i>α</i>/<i>β</i> hydrolase fold

David L. Ollis, Eong Cheah, Mirosław Cygler et al. · Protein Engineering Design and Selection · 1992 · 2.1K citations · Full text

, , +17

How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes

Alissa Rauwerdink, Romas J. Kazlauskas · ACS Catalysis · 2015 · 341 citations · Full text

, , +17

Derivation of 3D coordinate templates for searching structural databases: Application to ser‐His‐Asp catalytic triads in the serine proteinases and lipases

Andrew C. Wallace, Roman A. Laskowski, Janet M. Thornton · Protein Science · 1996 · 260 citations · Full text

, , +17

Role of the Catalytic Triad and Oxyanion Hole in Acetylcholinesterase Catalysis:  An ab initio QM/MM Study

Yingkai Zhang, Jeremy Kua, J. Andrew McCammon · Journal of the American Chemical Society · 2002 · 254 citations

, , +17

The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families

J.J.G. Tesmer, Thomas J. Klem, Michael L. Deras et al. · Nature Structural Biology · 1996 · 228 citations

, , +16

1–5 of 117

Authors

541

  1. ES
    Edith Sim

    University of Oxford, United Kingdom

    3 publications · 316 citations

    3

    h-index

  2. LP
    László Polgár

    Hungarian Academy of Sciences, Hungary

    3 publications · 109 citations

    3

    h-index

  3. JS
    James Sandy

    University of Oxford, United Kingdom

    2 publications · 248 citations

    2

    h-index

  4. JD
    Joseph D. Schrag

    Biotechnology Research Institute, Canada

    2 publications · 2.1K citations

    2

    h-index

  5. AB
    Antonio Bauzá

    Universitat de les Illes Balears, Spain

    2 publications · 87 citations

    2

    h-index

1–5 of 541

Institutions

244

  1. Rutgers, The State University of New Jersey

    New Brunswick, United States

    4 h-index

    11 publications

    2.3K citations

  2. Purdue University West Lafayette

    West Lafayette, United States

    4 h-index

    15 publications

    1.5K citations

  3. Australian National University

    Canberra, Australia

    3 h-index

    12 publications

    6.7K citations

  4. Zhejiang University

    Hangzhou, China

    3 h-index

    14 publications

    473 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    13 publications

    643 citations

  6. Argonne National Laboratory

    Lemont, United States

    3 h-index

    7 publications

    388 citations

  7. Institute of Molecular Life Sciences

    Budapest, Hungary

    3 h-index

    8 publications

    306 citations

  8. University of Oxford

    Oxford, United Kingdom

    3 h-index

    14 publications

    1.5K citations

1–8 of 244

Venues

  1. Journal of Biological Chemistry

    JBC · 14 publications · 945 citations

    14

    h-index

  2. Journal of the American Chemical Society

    JACS · 10 publications · 629 citations

    10

    h-index

  3. Biochemistry

    7 publications · 385 citations

    7

    h-index

  4. Protein Science

    PS · 4 publications · 496 citations

    4

    h-index

  5. Angewandte Chemie International Edition

    4 publications · 137 citations

    4

    h-index

1–5