Concepedia

Catalytic Triad Optimization

Catalytic Triad Optimization is a computational and experimental framework in enzyme engineering that systematically refines the spatial and electronic configuration of the catalytic triad residues to enhance catalytic efficiency and substrate specificity through targeted amino acid substitutions and quantum mechanical modeling.

25

Publications

949

Citations

170

Authors

69

Institutions

Publications per year

2017–2026

7

Parents

Publications

25

Design of activated serine–containing catalytic triads with atomic-level accuracy

S. Rajagopalan, Chu Wang, Kai Yu et al. · Nature Chemical Biology · 2014 · 88 citations · Full text

, , +16

Simple Design of an Enzyme-Inspired Supported Catalyst Based on a Catalytic Triad

Mitchell D. Nothling, Aravindhan Ganesan, Karmen Čondić‐Jurkić et al. · Chem · 2017 · 67 citations · Full text

, , +16

Application of combinatorial catalysis for the direct amination of benzene to aniline

Alfred Hagemeyer, Ramesh B. Borade, Peter J. Desrosiers et al. · Applied Catalysis A General · 2002 · 67 citations

, , +13

Identify catalytic triads of serine hydrolases by support vector machines

Yu‐Dong Cai, Guo‐Ping Zhou, Chin-Hung Jen et al. · Journal of Theoretical Biology · 2004 · 59 citations

, , +16

Enhanced α-Zearalenol Hydrolyzing Activity of a Mycoestrogen-Detoxifying Lactonase by Structure-Based Engineering

Zhongxia Xu, Weidong Liu, Chun‐Chi Chen et al. · ACS Catalysis · 2016 · 54 citations

, , +17

1–5 of 25

Authors

170

  1. HW
    Henry Weinberg

    Bayer (Germany), Germany

    2 publications · 107 citations

    2

    h-index

  2. GF
    Gerd Fengler

    Bayer (Germany), Germany

    2 publications · 107 citations

    2

    h-index

  3. SG
    Shenheng Guan

    University of California, San Francisco, United States

    2 publications · 107 citations

    2

    h-index

  4. DM
    Damodara M. Poojary

    Texas A&M University, United States

    2 publications · 107 citations

    2

    h-index

  5. AH
    Alfred Hagemeyer

    Max Planck Institute for Polymer Research, Germany

    2 publications · 107 citations

    2

    h-index

1–5 of 170

Institutions

69

  1. Bayer (Germany)

    Leverkusen, Germany

    2 h-index

    6 publications

    321 citations

  2. University of California, Berkeley

    Berkeley, United States

    2 h-index

    4 publications

    140 citations

  3. Universidade Federal de São Carlos

    São Carlos, Brazil

    1 h-index

    1 publications

    16 citations

  4. Universitat Politècnica de Catalunya

    Barcelona, Spain

    1 h-index

    4 publications

    72 citations

  5. The Gordon Life Science Institute

    Boston, United States

    1 h-index

    1 publications

    59 citations

  6. University of California, Santa Barbara

    Santa Barbara, United States

    1 h-index

    4 publications

    268 citations

  7. Ghent University

    Ghent, Belgium

    1 h-index

    6 publications

    132 citations

  8. University of Leeds

    Leeds, United Kingdom

    1 h-index

    1 publications

    59 citations

1–8 of 69

Venues

  1. ACS Catalysis

    2 publications · 100 citations

    2

    h-index

  2. Journal of Theoretical Biology

    2 publications · 80 citations

    2

    h-index

  3. Journal of Biological Chemistry

    JBC · 1 publications · 43 citations

    1

    h-index

  4. Frontiers in Chemistry

    1 publications · 34 citations

    1

    h-index

  5. Catalysis Today

    1 publications · 40 citations

    1

    h-index

1–5