Concepedia

Cargo Receptor Function

Cargo Receptor Function is a molecular mechanism that selectively binds misfolded proteins in the endoplasmic reticulum and targets them for retrotranslocation to the cytosol for degradation, distinguishing it from other protein trafficking mechanisms by its specificity for ER-associated degradation substrates.

100

Publications

9.5K

Citations

613

Authors

240

Institutions

Publications per year

2017–2026

54

Parents

Publications

100

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias, Xiaoxu Wang, Steven P. Gygi et al. · Nature · 2014 · 2K citations · Full text

, , +8

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

Joseph D. Mancias, Laura Pontano Vaites, Sahar Nissim et al. · eLife · 2015 · 531 citations · Full text

, , +15

Inhibiting Ferroptosis through Disrupting the NCOA4–FTH1 Interaction: A New Mechanism of Action

Yuying Fang, Xiu‐Cai Chen, Qingyun Tan et al. · ACS Central Science · 2021 · 504 citations · Full text

, , +15

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

Matthew D. Smith, Margaret E Harley, Alain J. Kemp et al. · Developmental Cell · 2017 · 448 citations · Full text

, , +15

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

Benjamin J. Ravenhill, Keith B. Boyle, Natalia von Muhlinen et al. · Molecular Cell · 2019 · 313 citations · Full text

, , +17

1–5 of 100

Authors

613

  1. KY
    Kazuo Yamamoto

    The University of Tokyo, Japan

    5 publications · 246 citations

    5

    h-index

  2. BT
    Brian T. Emmer

    University of Michigan, United States

    4 publications · 187 citations

    4

    h-index

  3. HH
    Hans‐Peter Hauri

    University of Basel, Switzerland

    4 publications · 484 citations

    4

    h-index

  4. VT
    Vi T. Tang

    University of Michigan, United States

    4 publications · 187 citations

    4

    h-index

  5. KS
    Kota Saito

    The University of Tokyo, Japan

    4 publications · 366 citations

    4

    h-index

1–5 of 613

Institutions

240

  1. The University of Tokyo

    Tokyo, Japan

    10 h-index

    31 publications

    2.3K citations

  2. University of Michigan

    Ann Arbor, United States

    7 h-index

    42 publications

    2.1K citations

  3. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    6 h-index

    18 publications

    3.3K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    7 publications

    523 citations

  5. University of Basel

    Basel, Switzerland

    4 h-index

    12 publications

    1.7K citations

  6. Japan Science and Technology Agency

    Tokyo, Japan

    4 h-index

    14 publications

    806 citations

  7. University of Vienna

    Vienna, Austria

    4 h-index

    28 publications

    2.4K citations

  8. Peking University

    Beijing, China

    4 h-index

    10 publications

    377 citations

1–8 of 240

Venues

  1. Autophagy

    10 publications · 800 citations

    10

    h-index

  2. The Journal of Cell Biology

    JCB · 7 publications · 773 citations

    8

    h-index

  3. Journal of Biological Chemistry

    JBC · 8 publications · 530 citations

    8

    h-index

  4. Molecular Biology of the Cell

    MBC · 6 publications · 419 citations

    6

    h-index

  5. eLife

    4 publications · 931 citations

    4

    h-index

1–5