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Perfusion-Driven Cardiac Tissue Engineering
2002 - 2015
The period is defined by a shift toward perfusion-based bioreactor maturation and dynamic conditioning for engineered cardiac tissues and valve constructs, with perfusion, pulsatile flow, stretch, and electrical cues driving tissue architecture, viability, and functional maturation. Emphasis on vascularized tissue engineering, optimized nutrient delivery, and scaffold-guided anisotropy consolidated research strategies that target thicker, clinically relevant grafts and translational potential. Collectively, researchers established a cohesive framework where microenvironment control and bioreactor design underpin the progression from in vitro models to regenerative therapies.
• Dynamic conditioning and bioreactor strategies for maturation across engineered cardiac tissues and valve constructs; perfusion, pulsatile flow, stretch, and electrical cues enhance tissue architecture and function, with evidence from multiple studies [4], [14], [13], [10], [12], [20], [11].
• Valve-focused engineering and translation: leaflets, autologous constructs, minimally invasive implantation, and pulsatile bioreactor shaping valve formation and function with clinical relevance [2], [3], [9], [13], [16], [20], [19].
• Vascularized cardiac tissue engineering and myocardial regeneration: enabling engineered myocardium with vascular networks and promoting engraftment in vivo [5], [8], [17], [15], [18].
• Oxygen and nutrient delivery optimization in thick constructs: computational and experimental strategies to overcome diffusion limits, including oxygen carriers, channel architectures and flow-based conditioning [6], [11], [4].
• Biomaterials and scaffolds guiding tissue engineering: fibrin carriers, myocardial matrix, anisotropic scaffolds and decellularized valve matrices enabling functional, scaffold-driven tissue formation [7], [17], [15], [18], [16].
In Situ Cardiac Biofabrication
2016 - 2022