Concepedia

Calcium-dependent Inactivation

Calcium-Dependent Inactivation is a regulatory mechanism of voltage-gated calcium channels in which the influx of calcium ions directly induces conformational changes that reduce channel open probability, thereby providing negative feedback to limit intracellular calcium overload during cardiac action potentials.

672

Publications

51.4K

Citations

2K

Authors

578

Institutions

Publications per year

2017–2026

45

Parents

Publications

672

Calmodulin supports both inactivation and facilitation of L-type calcium channels

Roger D. Zühlke, Geoffrey S. Pitt, Karl Deisseroth et al. · Nature · 1999 · 894 citations

, , +12

Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

A Fabiato · The Journal of General Physiology · 1985 · 891 citations · Full text

, , +14

A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones

Emilio Carbone, H. D. Lux · Nature · 1984 · 870 citations

, , +14

Calmodulin Is the Ca2+ Sensor for Ca2+-Dependent Inactivation of L-Type Calcium Channels

Blaise Z. Peterson, Carla D. DeMaria, David T. Yue · Neuron · 1999 · 851 citations · Full text

, , +17

Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.

Bruce P. Bean · The Journal of General Physiology · 1985 · 718 citations · Full text

, , +16

1–5 of 672

Authors

2K

  1. DT
    David T. Yue

    Johns Hopkins University, United States

    21 publications · 3K citations

    19

    h-index

  2. AL
    Amy Lee

    University of Iowa, United States

    9 publications · 459 citations

    9

    h-index

  3. RW
    Richard W. Tsien

    Stanford University, United States

    9 publications · 2.4K citations

    9

    h-index

  4. TW
    Tuck Wah Soong

    National University of Singapore, Singapore

    8 publications · 850 citations

    8

    h-index

  5. HR
    H. Réuter

    University of Bern, Switzerland

    8 publications · 2.5K citations

    8

    h-index

1–5 of 2K

Institutions

578

  1. Johns Hopkins University

    Baltimore, United States

    27 h-index

    114 publications

    18.5K citations

  2. Johns Hopkins Medicine

    Baltimore, United States

    23 h-index

    92 publications

    12.7K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    20 h-index

    71 publications

    2.8K citations

  4. Stanford University

    Stanford, United States

    18 h-index

    46 publications

    10K citations

  5. Inserm

    Paris, France

    16 h-index

    70 publications

    3.9K citations

  6. University of Iowa

    Iowa City, United States

    13 h-index

    29 publications

    1.5K citations

  7. National Institutes of Health

    Bethesda, United States

    13 h-index

    52 publications

    4.4K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    12 h-index

    32 publications

    6K citations

1–8 of 578

Venues

  1. The Journal of Physiology

    94 publications · 8.5K citations

    50

    h-index

  2. Journal of Biological Chemistry

    JBC · 52 publications · 4K citations

    37

    h-index

  3. The Journal of General Physiology

    JGP · 50 publications · 5.6K citations

    34

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 28 publications · 3.3K citations

    26

    h-index

  5. Journal of Neuroscience

    24 publications · 2K citations

    23

    h-index

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