Bioimage registration is a computational methodology for spatially aligning multiple biological images, often acquired under different conditions such as varying time points, imaging modalities, or samples. As a significant research area within bioimage analysis, it investigates algorithms and techniques to establish accurate geometric correspondence between images, addressing challenges like deformation, noise, and intensity variations. Its core significance lies in enabling robust downstream quantitative analyses, including tracking, atlas construction, and comparative studies, which are fundamental for extracting meaningful biological information and understanding complex dynamic processes.