Concepedia

Bioactivation Kinetics

Bioactivation Kinetics is the branch of pharmacokinetics that characterizes the rate and extent of metabolic conversion of a pharmacologically inactive prodrug into its active form within the oral delivery pathway.

35

Publications

2.1K

Citations

155

Authors

62

Institutions

Publications per year

2017–2026

9

Parents

Publications

35

Bioactivation as a Model for Drug Design Bioreductive Alkylation

Harold W. Moore · Science · 1977 · 433 citations

, , +5

Improved high bioactivation cross for the wing somatic mutation and recombination test in Drosophila melanogaster

Ulrich Gräf, Nancy van Schaik · Mutation Research/Environmental Mutagenesis and Related Subjects · 1992 · 213 citations

, , +14

V. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Neal Castagnoli, Kazuhiro Chiba, Anthony J. Trevor · Life Sciences · 1985 · 151 citations

, , +11

Nepafenac, a Unique Nonsteroidal Prodrug with Potential Utility in the Treatment of Trauma-Induced Ocular Inflammation: II. In Vitro Bioactivation and Permeation of External Ocular Barriers

Tai-Lee Ke, Gustav Graff, Joan M. Spellman et al. · Inflammation · 2000 · 133 citations

, , +14

Microbiological assay of bleomycin: Inactivation, tissue distribution, and clearance

Takao Ohnuma, James F. Holland, Hisayuki Masuda et al. · Cancer · 1974 · 128 citations

, , +15

1–5 of 35

Authors

155

  1. IM
    Ivonne M.C.M. Rietjens

    Wageningen University & Research, Netherlands

    3 publications · 199 citations

    3

    h-index

  2. AS
    Amit S. Kalgutkar

    Pfizer (United States), United States

    2 publications · 127 citations

    2

    h-index

  3. TD
    Thierry Delatour

    Nestlé (Switzerland), Switzerland

    2 publications · 183 citations

    2

    h-index

  4. PJ
    Peter J. van Bladeren

    Wageningen University & Research, Netherlands

    2 publications · 183 citations

    2

    h-index

  5. RS
    R. Scott Obach

    Pfizer (United States), United States

    2 publications · 127 citations

    2

    h-index

1–5 of 155

Institutions

62

  1. Wageningen University & Research

    Wageningen, The Netherlands

    4 h-index

    16 publications

    910 citations

  2. University of Zurich

    Zurich, Switzerland

    2 h-index

    3 publications

    287 citations

  3. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    2 h-index

    3 publications

    287 citations

  4. Pfizer (United States)

    New York, United States

    2 h-index

    7 publications

    347 citations

  5. Nestlé (Switzerland)

    Vevey, Switzerland

    2 h-index

    11 publications

    1K citations

  6. University of Arizona

    Tucson, United States

    1 h-index

    9 publications

    108 citations

  7. King Saud University

    Riyadh, Saudi Arabia

    1 h-index

    3 publications

    129 citations

  8. Irvine University

    Cerritos, United States

    1 h-index

    1 publications

    433 citations

1–8 of 62

Venues

  1. Drug Metabolism and Disposition

    7 publications · 271 citations

    7

    h-index

  2. Journal of Biological Chemistry

    JBC · 2 publications · 79 citations

    2

    h-index

  3. Journal of Medicinal Chemistry

    2 publications · 57 citations

    2

    h-index

  4. Bioorganic & Medicinal Chemistry

    2 publications · 71 citations

    2

    h-index

  5. Food and Chemical Toxicology

    2 publications · 53 citations

    2

    h-index

1–5