Concepedia

Binding Pocket Occlusion

Binding Pocket Occlusion is a structural phenomenon in molecular modeling where the access to a protein's binding site is sterically hindered by neighboring atoms or residues, thereby reducing ligand accessibility and influencing molecular recognition within the framework of excluded volume effects.

13

Publications

2.4K

Citations

65

Authors

33

Institutions

Publications per year

2017–2026

2

Parents

Publications

13

Anatomy of protein pockets and cavities: Measurement of binding site geometry and implications for ligand design

Jie Liang, Clare Woodward, Herbert Edelsbrunner · Protein Science · 1998 · 1.1K citations · Full text

, , +17

Crystal Structure of a Lipid G Protein–Coupled Receptor

Michael A. Hanson, C. Roth, Euijung Jo et al. · Science · 2012 · 668 citations

, , +17

Van der Waals Interactions Dominate Ligand−Protein Association in a Protein Binding Site Occluded from Solvent Water

Elizabeth Barratt, Richard J. Bingham, Daniel J. Warner et al. · Journal of the American Chemical Society · 2005 · 188 citations

, , +16

Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger

Jun Liao, Fabrizio Marinelli, Changkeun Lee et al. · Nature Structural & Molecular Biology · 2016 · 107 citations · Full text

, , +16

Chloride binding site of neurotransmitter sodium symporters

Adriana K. Kantcheva, Matthias Quick, Lei Shi et al. · Proceedings of the National Academy of Sciences · 2013 · 93 citations · Full text

, , +13

1–5 of 13

Authors

65

  1. VH
    Volkhard Helms

    Saarland University, Germany

    1 publications · 62 citations

    1

    h-index

  2. RC
    Raymond C. Stevens

    Scripps Research Institute, United States

    1 publications · 668 citations

    1

    h-index

  3. MA
    Michael A. Hanson

    Scripps Research Institute, United States

    1 publications · 668 citations

    1

    h-index

  4. JA
    Jonathan A. Javitch

    Columbia University, United States

    1 publications · 93 citations

    1

    h-index

  5. SM
    Stuart M. Cahalan

    Scripps Research Institute, United States

    1 publications · 668 citations

    1

    h-index

1–5 of 65

Institutions

33

  1. Laboratoire Hétéroéléments et Coordination

    Palaiseau, France

    1 h-index

    2 publications

    186 citations

  2. University of Oxford

    Oxford, United Kingdom

    1 h-index

    4 publications

    56 citations

  3. Aarhus University

    Aarhus, Denmark

    1 h-index

    3 publications

    279 citations

  4. Columbia University

    New York, United States

    1 h-index

    1 publications

    93 citations

  5. Texas Tech University

    Lubbock, United States

    1 h-index

    1 publications

    50 citations

  6. National Heart Lung and Blood Institute

    Bethesda, United States

    1 h-index

    2 publications

    214 citations

  7. University of Copenhagen

    Copenhagen, Denmark

    1 h-index

    3 publications

    168 citations

  8. Texas Tech University Health Sciences Center

    Lubbock, United States

    1 h-index

    1 publications

    50 citations

1–8 of 33

Venues

  1. Biochemistry

    2 publications · 54 citations

    2

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 93 citations

    1

    h-index

  3. Journal of Chemical Theory and Computation

    JCTC · 1 publications · 12 citations

    1

    h-index

  4. Journal of Computer-Aided Molecular Design

    1 publications · 62 citations

    1

    h-index

  5. Nature Structural & Molecular Biology

    1 publications · 107 citations

    1

    h-index

1–5