Concepedia

Biallelic Inactivation

Biallelic Inactivation is a genetic phenomenon in which both alleles of a gene are inactivated through mutations or epigenetic modifications, leading to the complete loss of functional gene expression, particularly relevant in tumor suppressor genes during carcinogenesis.

194

Publications

20.1K

Citations

3.1K

Authors

815

Institutions

Publications per year

2017–2026

60

Parents

Publications

194

Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia

Niall G. Howlett, Toshiyasu Taniguchi, Susan B. Olson et al. · Science · 2002 · 1.1K citations

, , +13

The evolutionary history of 2,658 cancers

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner et al. · Nature · 2020 · 1.1K citations · Full text

, , +17

The Genetic Evolution of Melanoma from Precursor Lesions

A. Hunter Shain, Iwei Yeh, Ivanka Kovalyshyn et al. · New England Journal of Medicine · 2015 · 1.1K citations · Full text

, , +17

Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

Anju Singh, Vikas Misra, Rajesh K. Thimmulappa et al. · PLoS Medicine · 2006 · 1K citations · Full text

, , +13

Biallelic inactivation of <i> hMLH <i>1</i> </i> by epigenetic gene silencing, a novel mechanism causing human MSI cancers

Martina Veigl, Lakshmi Kasturi, Joseph Olechnowicz et al. · Proceedings of the National Academy of Sciences · 1998 · 635 citations · Full text

, , +17

1–5 of 194

Authors

3.1K

  1. LA
    Lauri A. Aaltonen

    University of Helsinki, Finland

    4 publications · 1.5K citations

    4

    h-index

  2. IC
    Ian Campbell

    Peter MacCallum Cancer Centre, Australia

    3 publications · 237 citations

    4

    h-index

  3. HJ
    Heikki Järvinen

    Helsinki University Hospital, Finland

    3 publications · 417 citations

    3

    h-index

  4. BT
    Bin Tean Teh

    National Cancer Centre Singapore, Singapore

    3 publications · 1.4K citations

    3

    h-index

  5. MQ
    Miguel Quijada‐Álamo

    Instituto de Investigación Biomédica de Salamanca, Spain

    3 publications · 72 citations

    3

    h-index

1–5 of 3.1K

Institutions

815

  1. Harvard University

    Cambridge, United States

    12 h-index

    43 publications

    20.7K citations

  2. Dana-Farber Cancer Institute

    Boston, United States

    12 h-index

    40 publications

    22.1K citations

  3. Inserm

    Paris, France

    10 h-index

    29 publications

    3.6K citations

  4. The University of Melbourne

    Melbourne, Australia

    9 h-index

    47 publications

    37K citations

  5. Memorial Sloan Kettering Cancer Center

    New York, United States

    9 h-index

    122 publications

    32.4K citations

  6. Johns Hopkins University

    Baltimore, United States

    8 h-index

    60 publications

    28.6K citations

  7. University of Helsinki

    Helsinki, Finland

    8 h-index

    57 publications

    15.3K citations

  8. Brigham and Women's Hospital

    Boston, United States

    8 h-index

    16 publications

    4.4K citations

1–8 of 815

Venues

  1. PubMed

    Repository · 17 publications · 1.9K citations

    16

    h-index

  2. Cancer Research

    11 publications · 1.4K citations

    11

    h-index

  3. Genes Chromosomes and Cancer

    8 publications · 306 citations

    8

    h-index

  4. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 7 publications · 495 citations

    7

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 1.4K citations

    7

    h-index

1–5