Concepedia

Beta-lactamase Evolution

Beta-Lactamase Evolution is a theoretical construct in microbiological research that delineates the progressive genetic and structural modifications in beta-lactamase enzymes, enabling Gram-negative bacteria to enhance hydrolytic resistance to beta-lactam antibiotics through natural selection and horizontal gene transfer.

754

Publications

45.5K

Citations

3.2K

Authors

1.1K

Institutions

Publications per year

2017–2026

168

Parents

Publications

754

The structure of β-lactamases

R P Ambler · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1980 · 1.8K citations

, , +12

Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins

Daniel Weinreich, Nigel F. Delaney, Mark A. DePristo et al. · Science · 2006 · 1.5K citations

, , +17

CTX-M Enzymes: Origin and Diffusion

Rafael Cantón, José María González‐Alba, Juan Carlos Galán · Frontiers in Microbiology · 2012 · 962 citations · Full text

, , +17

Beta-lactamase database (BLDB) – structure and function

Thierry Naas, Saoussen Oueslati, Rémy A. Bonnin et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 · 686 citations · Full text

, , +15

The Epidemic of Extended-Spectrum-β-Lactamase-Producing Escherichia coli ST131 Is Driven by a Single Highly Pathogenic Subclone, <i>H</i> 30-Rx

Lance B. Price, James R. Johnson, Maliha Aziz et al. · mBio · 2013 · 479 citations · Full text

, , +17

1–5 of 754

Authors

3.2K

  1. PN
    Patrice Nordmann

    Bicêtre Hospital, France

    30 publications · 2.1K citations

    26

    h-index

  2. LP
    Laurent Poirel

    Bicêtre Hospital, France

    26 publications · 1.9K citations

    24

    h-index

  3. RA
    Robert A. Bonomo

    Louis Stokes Cleveland VA Medical Center, United States

    26 publications · 1.3K citations

    21

    h-index

  4. GM
    Gian María Rossolini

    University of Siena, Italy

    19 publications · 1.4K citations

    18

    h-index

  5. TP
    Timothy Palzkill

    Baylor College of Medicine, United States

    15 publications · 904 citations

    14

    h-index

1–5 of 3.2K

Institutions

1.1K

  1. Assistance Publique – Hôpitaux de Paris

    Paris, France

    32 h-index

    147 publications

    14.9K citations

  2. Inserm

    Paris, France

    28 h-index

    103 publications

    8.7K citations

  3. Bicêtre Hospital

    Le Kremlin-Bicêtre, France

    23 h-index

    74 publications

    9.3K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    22 h-index

    77 publications

    7.9K citations

  5. Louis Stokes Cleveland VA Medical Center

    Cleveland, United States

    19 h-index

    85 publications

    4.7K citations

  6. Case Western Reserve University

    Cleveland, United States

    19 h-index

    67 publications

    4.6K citations

  7. University of Siena

    Siena, Italy

    17 h-index

    50 publications

    3.1K citations

  8. Baylor College of Medicine

    Houston, United States

    14 h-index

    56 publications

    3.2K citations

1–8 of 1.1K

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 197 publications · 12.4K citations

    62

    h-index

  2. Journal of Antimicrobial Chemotherapy

    JAC · 47 publications · 2.8K citations

    31

    h-index

  3. International Journal of Antimicrobial Agents

    24 publications · 811 citations

    17

    h-index

  4. Diagnostic Microbiology and Infectious Disease

    17 publications · 568 citations

    16

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 2.4K citations

    15

    h-index

1–5