Concepedia

Concept

bcr gene

Parents

113

Publications

12.3K

Citations

567

Authors

155

Institutions

About

Bcr gene is an abbreviation for the Breakpoint Cluster Region gene, located on human chromosome 22, and represents a fundamental concept in molecular biology and cancer research. It is primarily investigated for its critical involvement in recurrent chromosomal translocations, most notably the t(9;22) translocation that fuses it with the ABL1 gene from chromosome 9, resulting in the oncogenic BCR-ABL1 fusion gene. Research on the bcr gene examines its normal cellular function, its role in the pathogenesis of chronic myeloid leukemia (CML) and other hematological malignancies, and its significance as a diagnostic marker and target for therapeutic intervention.

Top Authors

Rankings shown are based on concept H-Index.

NH

Children's Hospital of Los Angeles

JG

Children's Hospital of Los Angeles

MT

The University of Texas MD Anderson Cancer Center

ON

University of California, Los Angeles

RK

The University of Texas MD Anderson Cancer Center

Top Institutions

Rankings shown are based on concept H-Index.

Children's Hospital of Los Angeles

Los Angeles, United States

University of California San Diego

San Diego, United States

Howard Hughes Medical Institute

Chevy Chase, United States

University of California, Los Angeles

Los Angeles, United States