Concepedia

Batch-to-continuous Scale-up

Batch-to-Continuous Scale-Up is a scale-up design methodology that transitions chemical or pharmaceutical processes from discrete batch operations to continuous flow systems, distinguishing itself by enabling improved process control, reproducibility, and scalability through sustained operational steady states.

50

Publications

3.4K

Citations

254

Authors

71

Institutions

Publications per year

2017–2026

28

Parents

Publications

50

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

Andrea Adamo, Rachel L. Beingessner, Mohsen Behnam et al. · Science · 2016 · 937 citations

, , +16

Continuous Flow Techniques in Organic Synthesis

Gerhard Jas, Andreas Kirschning · Chemistry - A European Journal · 2003 · 469 citations

, , +15

Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes

Markus Damm, Toma Glasnov, C. Oliver Kappe · Organic Process Research & Development · 2009 · 139 citations

, , +16

Pilot plants, models, and scale-up methods in chemical engineering

Wilbur S. Hall · Journal of the Franklin Institute · 1957 · 135 citations

, , +16

Process Development and Scale Up: III. Scale-up and scale-down of trickle bed processes

S.T. Sie, Rajamani Krishna · Reviews in Chemical Engineering · 1998 · 116 citations

, , +15

1–5 of 50

Authors

254

  1. MD
    Martin D. Johnson

    Eli Lilly (United States), United States

    3 publications · 137 citations

    3

    h-index

  2. SS
    S.T. Sie

    Delft University of Technology, Netherlands

    2 publications · 144 citations

    2

    h-index

  3. DR
    David R. Snead

    Massachusetts Institute of Technology, United States

    1 publications · 937 citations

    2

    h-index

  4. RK
    Rajamani Krishna

    University of Amsterdam, Netherlands

    2 publications · 144 citations

    2

    h-index

  5. NE
    Nicholas E. Leadbeater

    University of Connecticut, United States

    2 publications · 206 citations

    2

    h-index

1–5 of 254

Institutions

71

  1. Eli Lilly (United States)

    Indianapolis, United States

    4 h-index

    23 publications

    995 citations

  2. University of Connecticut

    Storrs, United States

    3 h-index

    8 publications

    777 citations

  3. University of Nottingham

    Nottingham, United Kingdom

    2 h-index

    7 publications

    154 citations

  4. Virginia Commonwealth University

    Richmond, United States

    2 h-index

    7 publications

    287 citations

  5. Purdue University West Lafayette

    West Lafayette, United States

    2 h-index

    3 publications

    81 citations

  6. Natural (Czechia)

    Hradištko, Czechia

    1 h-index

    12 publications

    120 citations

  7. Qingdao University of Science and Technology

    Qingdao, China

    1 h-index

    6 publications

    156 citations

  8. University of Chemistry and Technology, Prague

    Prague, Czechia

    1 h-index

    2 publications

    42 citations

1–8 of 71

Venues

  1. Organic Process Research & Development

    14 publications · 739 citations

    13

    h-index

  2. Reaction Chemistry & Engineering

    3 publications · 91 citations

    3

    h-index

  3. Reviews in Chemical Engineering

    2 publications · 144 citations

    2

    h-index

  4. Data Archiving and Networked Services (DANS)

    Repository · 1 publications · 18 citations

    1

    h-index

  5. Journal of Flow Chemistry

    1 publications · 15 citations

    1

    h-index

1–5