Concepedia

Backbone N-methylation

Backbone N-Methylation is a chemical modification strategy in macrocyclic drug design wherein a methyl group is selectively introduced to a nitrogen atom within the peptide backbone, enhancing metabolic stability and membrane permeability while preserving the core conformational architecture of the macrocycle.

78

Publications

5.2K

Citations

391

Authors

115

Institutions

Publications per year

2017–2026

26

Parents

Publications

78

N-methoxy-n-methylamides as effective acylating agents

Steven Nahm, Steven M. Weinreb · Tetrahedron Letters · 1981 · 1.8K citations

, , +5

Improving Oral Bioavailability of Peptides by Multiple N‐Methylation: Somatostatin Analogues

Éric Biron, Jayanta Chatterjee, Oded Ovadia et al. · Angewandte Chemie International Edition · 2008 · 372 citations · Full text

, , +14

Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified

Jayanta Chatterjee, Burkhardt Laufer, Andreas O. Frank et al. · Journal of the American Chemical Society · 2012 · 188 citations

, , +17

Oxybenzotriazole free peptide coupling reagents for N-methylated amino acids

J. H. Coste, Eric Frérot, Patrick Jouin et al. · Tetrahedron Letters · 1991 · 182 citations

, , +9

Synthesis of N-methylated cyclic peptides

Jayanta Chatterjee, Burkhardt Laufer, Horst Kessler · Nature Protocols · 2012 · 132 citations

, , +6

1–5 of 78

Authors

391

  1. HK
    Horst Kessler

    Technical University of Munich, Germany

    8 publications · 945 citations

    8

    h-index

  2. JC
    Jayanta Chatterjee

    Technical University of Munich, Germany

    5 publications · 761 citations

    5

    h-index

  3. MK
    Markus Künzler

    ETH Zurich, Switzerland

    4 publications · 231 citations

    5

    h-index

  4. CG
    Chaim Gilon

    Hebrew University of Jerusalem, Israel

    5 publications · 646 citations

    5

    h-index

  5. AO
    Andreas O. Frank

    Technical University of Munich, Germany

    4 publications · 277 citations

    4

    h-index

1–5 of 391

Institutions

115

  1. ETH Zurich

    Zurich, Switzerland

    8 h-index

    36 publications

    1.9K citations

  2. Center for Integrated Protein Science Munich

    Munich, Germany

    8 h-index

    39 publications

    3.5K citations

  3. Technical University of Munich

    Munich, Germany

    7 h-index

    34 publications

    4.2K citations

  4. Institute for Advanced Study

    Berlin, Germany

    5 h-index

    29 publications

    3K citations

  5. Novartis (Switzerland)

    Basel, Switzerland

    4 h-index

    11 publications

    1.9K citations

  6. Hebrew University of Jerusalem

    Jerusalem, Israel

    4 h-index

    19 publications

    2.3K citations

  7. King Abdulaziz University

    Jeddah, Saudi Arabia

    4 h-index

    4 publications

    402 citations

  8. Biotechnology Institute

    Washington D.C., United States

    3 h-index

    7 publications

    401 citations

1–8 of 115

Venues

  1. Journal of Medicinal Chemistry

    9 publications · 320 citations

    9

    h-index

  2. Journal of the American Chemical Society

    JACS · 5 publications · 360 citations

    6

    h-index

  3. ACS Chemical Biology

    4 publications · 85 citations

    4

    h-index

  4. Journal of Biological Chemistry

    JBC · 4 publications · 91 citations

    4

    h-index

  5. Tetrahedron Letters

    4 publications · 2K citations

    4

    h-index

1–5