Concepedia

Astrocyte Complement Signaling

Astrocyte Complement Signaling is a molecular signaling mechanism wherein astrocytes express and regulate components of the complement system to mediate neuroimmune crosstalk, synaptic pruning, and central nervous system inflammation in a context-dependent manner.

53

Publications

3.6K

Citations

361

Authors

140

Institutions

Publications per year

2017–2026

25

Parents

Publications

53

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

Hong Lian, Alexandra Litvinchuk, Angie C.A. Chiang et al. · Journal of Neuroscience · 2016 · 600 citations · Full text

, , +17

Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines.

Philippe Gasque, Michele Fontaine, B. Paul Morgan · The Journal of Immunology · 1995 · 238 citations

, , +15

Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system.

Philippe Gasque, Sim K. Singhrao, J. W. Neal et al. · PubMed · 1997 · 237 citations

, , +15

Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

Tatsuro Misu, Romana Höftberger, Kazuo Fujihara et al. · Acta Neuropathologica · 2013 · 230 citations · Full text

, , +17

Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes

Philippe Gasque, Philippe Chan, Marc Fontaine et al. · The Journal of Immunology · 1995 · 167 citations

, , +17

1–5 of 53

Authors

361

  1. PG
    Philippe Gasque

    University of Wales, United Kingdom

    6 publications · 747 citations

    6

    h-index

  2. MF
    Marc Fontaine

    Inserm, France

    5 publications · 419 citations

    5

    h-index

  3. BP
    B. Paul Morgan

    Cardiff University, United Kingdom

    4 publications · 660 citations

    4

    h-index

  4. AI
    A. Ischenko

    State Research Institute of Highly Pure Biopreparations, Russia

    4 publications · 338 citations

    4

    h-index

  5. SS
    Sakina Sayah

    Inserm, France

    3 publications · 171 citations

    3

    h-index

1–5 of 361

Institutions

140

  1. Inserm

    Paris, France

    5 h-index

    18 publications

    1.2K citations

  2. University of Wales

    Cardiff, United Kingdom

    4 h-index

    9 publications

    1.1K citations

  3. State Research Institute of Highly Pure Biopreparations

    Saint Petersburg, Russia

    3 h-index

    3 publications

    171 citations

  4. Mayo Clinic

    Rochester, United States

    3 h-index

    9 publications

    708 citations

  5. University of California, San Francisco

    San Francisco, United States

    3 h-index

    6 publications

    250 citations

  6. Mayo Clinic in Florida

    Jacksonville, United States

    2 h-index

    3 publications

    234 citations

  7. Union Hospital

    Shatin, China

    2 h-index

    8 publications

    217 citations

  8. Huaqiao University

    Xiamen, China

    2 h-index

    7 publications

    433 citations

1–8 of 140

Venues

  1. Journal of Neuroinflammation

    JNI · 6 publications · 189 citations

    6

    h-index

  2. The Journal of Immunology

    JI · 3 publications · 483 citations

    3

    h-index

  3. Brain Behavior and Immunity

    3 publications · 113 citations

    3

    h-index

  4. Molecular Brain Research

    3 publications · 134 citations

    3

    h-index

  5. Journal of Neurochemistry

    JNC · 2 publications · 143 citations

    2

    h-index

1–5