Concepedia

Aptamer Specificity Optimization

Aptamer Specificity Optimization is a methodological framework in nucleic acid aptamer evolution that systematically enhances the selective binding affinity of an aptamer toward a target molecule while minimizing cross-reactivity with non-target entities.

37

Publications

1.7K

Citations

200

Authors

104

Institutions

Publications per year

2017–2026

22

Parents

Publications

37

Perspective on the Future Role of Aptamers in Analytical Chemistry

Yao Wu, Israel Belmonte, Kiana S. Sykes et al. · Analytical Chemistry · 2019 · 167 citations · Full text

, , +15

Aptamers Selected for Higher-Affinity Binding Are Not More Specific for the Target Ligand

James M. Carothers, Stephanie Oestreich, Jack W. Szostak · Journal of the American Chemical Society · 2006 · 131 citations · Full text

, , +16

Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing

Alexey Berezhnoy, Charles A. Stewart, James O McNamara et al. · Molecular Therapy · 2012 · 122 citations · Full text

, , +12

Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G

Shin Miyakawa, Yusuke Nomura, Taiichi Sakamoto et al. · RNA · 2008 · 119 citations · Full text

, , +17

Novel Combinatorial Selection of Phosphorothioate Oligonucleotide Aptamers

David J. King, Daniel A. Ventura, Allan R. Brasier et al. · Biochemistry · 1998 · 98 citations

, , +15

1–5 of 37

Authors

200

  1. KA
    Koichi Abe

    Tokyo University of Agriculture and Technology, Japan

    3 publications · 101 citations

    3

    h-index

  2. KI
    Kazunori Ikebukuro

    Tokyo University of Agriculture and Technology, Japan

    3 publications · 101 citations

    3

    h-index

  3. WY
    Wataru Yoshida

    Tokyo University of Agriculture and Technology, Japan

    3 publications · 101 citations

    3

    h-index

  4. NS
    Nasa Savory

    Tokyo University of Agriculture and Technology, Japan

    3 publications · 101 citations

    3

    h-index

  5. KT
    Kaori Tsukakoshi

    Tokyo University of Agriculture and Technology, Japan

    3 publications · 101 citations

    3

    h-index

1–5 of 200

Institutions

104

  1. Tokyo University of Agriculture and Technology

    Tokyo, Japan

    3 h-index

    22 publications

    714 citations

  2. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    3 publications

    105 citations

  3. Shandong Normal University

    Jinan, China

    2 h-index

    10 publications

    270 citations

  4. Jiangnan University

    Wuxi, China

    2 h-index

    10 publications

    580 citations

  5. Lomonosov Moscow State University

    Moscow, Russia

    1 h-index

    1 publications

    28 citations

  6. The University of Texas Medical Branch at Galveston

    Galveston, United States

    1 h-index

    9 publications

    252 citations

  7. European Molecular Biology Laboratory

    Hamburg, Germany

    1 h-index

    1 publications

    28 citations

  8. University of Cincinnati

    Cincinnati, United States

    1 h-index

    4 publications

    668 citations

1–8 of 104

Venues

  1. Nucleic Acids Research

    2 publications · 133 citations

    2

    h-index

  2. Biotechnology and Bioengineering

    2 publications · 77 citations

    2

    h-index

  3. Analytical Chemistry

    2 publications · 200 citations

    2

    h-index

  4. Molecular Therapy — Nucleic Acids

    2 publications · 59 citations

    2

    h-index

  5. Biochemistry

    2 publications · 126 citations

    2

    h-index

1–5