Concepedia

Antibody Framework Selection

Antibody Framework Selection is the systematic process of choosing a foundational immunoglobulin scaffold for chimeric antibody design, distinguished by the integration of donor-derived variable region sequences into an acceptor framework to optimize structural stability, specificity, and reduced immunogenicity.

35

Publications

2.2K

Citations

202

Authors

74

Institutions

Publications per year

2017–2026

2

Parents

Publications

35

Antibody framework residues affecting the conformation of the hypervariable loops

Jefferson Foote, Greg Winter · Journal of Molecular Biology · 1992 · 535 citations

, , +13

Identification of a Universal VHH Framework to Graft Non-canonical Antigen-binding Loops of Camel Single-domain Antibodies

Dirk Saerens, Mireille Pellis, Remy Loris et al. · Journal of Molecular Biology · 2005 · 254 citations

, , +16

Improving in vivo folding and stability of a single-chain Fv antibody fragment by loop grafting

Sora Jung, Andreas Plückthun · Protein Engineering Design and Selection · 1997 · 155 citations · Full text

, , +17

Contributions of CDR3 to VHH Domain Stability and the Design of Monobody Scaffolds for Naive Antibody Libraries

Christopher J. Bond, James C. Marsters, Sachdev S. Sidhu · Journal of Molecular Biology · 2003 · 98 citations

, , +16

The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies

Verónica Quintero‐Hernández, Víctor Rivelino Juárez-González, Mauricio Ortíz-León et al. · Molecular Immunology · 2006 · 94 citations

, , +15

1–5 of 35

Authors

202

  1. JF
    Jiannan Feng

    Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences

    2 publications · 46 citations

    2

    h-index

  2. AP
    Andreas Plückthun

    University of Zurich, Switzerland

    2 publications · 219 citations

    2

    h-index

  3. HP
    Hung‐Pin Peng

    Genomics Research Center, Academia Sinica, Taiwan

    2 publications · 43 citations

    2

    h-index

  4. JJ
    Jhih-Wei Jian

    Genomics Research Center, Academia Sinica, Taiwan

    2 publications · 43 citations

    2

    h-index

  5. AY
    An‐Suei Yang

    Genomics Research Center, Academia Sinica, Taiwan

    2 publications · 43 citations

    2

    h-index

1–5 of 202

Institutions

74

  1. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    26 publications

    1.1K citations

  2. Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences

    Beijing, China

    2 h-index

    9 publications

    272 citations

  3. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    2 h-index

    3 publications

    1.1K citations

  4. University of Zurich

    Zurich, Switzerland

    2 h-index

    9 publications

    758 citations

  5. Genomics Research Center, Academia Sinica

    Taipei, Taiwan

    2 h-index

    31 publications

    624 citations

  6. The University of Osaka

    Osaka, Japan

    1 h-index

    4 publications

    324 citations

  7. Beijing Institute of Education

    Beijing, China

    1 h-index

    2 publications

    20 citations

  8. Université de Technologie de Compiègne

    Compiègne, France

    1 h-index

    5 publications

    120 citations

1–8 of 74

Venues

  1. Journal of Molecular Biology

    JMB · 5 publications · 994 citations

    5

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 4 publications · 272 citations

    4

    h-index

  3. Journal of Immunological Methods

    4 publications · 75 citations

    4

    h-index

  4. Molecular Immunology

    3 publications · 142 citations

    3

    h-index

  5. Journal of Biological Chemistry

    JBC · 2 publications · 52 citations

    2

    h-index

1–5