Concepedia

Antibody Format Selection

Antibody Format Selection is the systematic process of choosing a specific structural and functional configuration of an antibody molecule—such as full-length IgG, fragment formats (e.g., Fab, scFv), or engineered derivatives (e.g., bispecific, multispecific, or fusion constructs)—based on desired pharmacokinetic, stability, tissue penetration, immunogenicity, and functional efficacy criteria within the context of diagnostic application development.

7

Publications

342

Citations

99

Authors

36

Institutions

Publications per year

2017–2026

4

Parents

Publications

7

Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration

Bryan Smith, Rocío Lledó‐García, Kate L. Dixon et al. · mAbs · 2018 · 110 citations · Full text

, , +17

The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies

Verónica Quintero‐Hernández, Víctor Rivelino Juárez-González, Mauricio Ortíz-León et al. · Molecular Immunology · 2006 · 94 citations

, , +15

Formatted single-domain antibodies can protect mice against infection with influenza virus (H5N2)

M. V. Rutovskaya, Seda A. Saakyan, Irina Y. Gribova et al. · Antiviral Research · 2012 · 54 citations

, , +14

Neutralizing Antibody Validation Testing and Reporting Harmonization

Heather Myler, João Pedras-Vasconcelos, Todd Lester et al. · The AAPS Journal · 2023 · 26 citations · Full text

, , +14

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies

Hanine Rafidi, Sharmila Rajan, Konnie Urban et al. · mAbs · 2022 · 22 citations · Full text

, , +17

1–5 of 7

Authors

99

  1. BW
    Bonnie Wu

    Janssen (United States), United States

    1 publications · 26 citations

    1

    h-index

  2. MY
    Montarop Yamabhai

    Suranaree University of Technology, Thailand

    1 publications · 16 citations

    1

    h-index

  3. SW
    Shauna West

    UCB Pharma (United Kingdom), United Kingdom

    1 publications · 110 citations

    1

    h-index

  4. HM
    Helene M. Finney

    UCB Pharma (United Kingdom), United Kingdom

    1 publications · 110 citations

    1

    h-index

  5. WS
    Whitney Shatz-Binder

    PDL BioPharma (United States), United States

    1 publications · 22 citations

    1

    h-index

1–5 of 99

Institutions

36

  1. Institute of Molecular Biotechnology

    Vienna, Austria

    1 h-index

    2 publications

    32 citations

  2. Regenxbio (United States)

    Rockville, United States

    1 h-index

    1 publications

    26 citations

  3. Pharmaceutical Product Development (United States)

    Wilmington, United States

    1 h-index

    2 publications

    52 citations

  4. Center for Drug Evaluation and Research

    Silver Spring, United States

    1 h-index

    2 publications

    52 citations

  5. Bristol-Myers Squibb (United States)

    New York, United States

    1 h-index

    3 publications

    78 citations

  6. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    1 h-index

    2 publications

    52 citations

  7. Shiraz University

    Shiraz, Iran

    1 h-index

    1 publications

    20 citations

  8. Dublin City University

    Dublin, Ireland

    1 h-index

    1 publications

    16 citations

1–8 of 36

Venues

  1. mAbs

    2 publications · 132 citations

    2

    h-index

  2. ACS Omega

    1 publications · 16 citations

    1

    h-index

  3. Molecular Immunology

    1 publications · 94 citations

    1

    h-index

  4. Journal of Theoretical Biology

    1 publications · 20 citations

    1

    h-index

  5. The AAPS Journal

    AAPSJ · 1 publications · 26 citations

    1

    h-index

1–5