Concepedia

Amyloid Polymorphism

Amyloid Polymorphism is a structural phenomenon in which a single protein sequence forms amyloid fibrils with multiple distinct molecular architectures under identical environmental conditions, differing in their underlying supramolecular organization despite shared cross-β spine motifs.

376

Publications

24.4K

Citations

2.3K

Authors

853

Institutions

Publications per year

2017–2026

103

Variants

Amyloid Structural Polymorphism

Parents

Publications

376

Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils

Aneta T. Petkova, Richard D. Leapman, Zhihong Guo et al. · Science · 2005 · 1.7K citations

, , +17

Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils

Anant K. Paravastu, Richard D. Leapman, Wai‐Ming Yau et al. · Proceedings of the National Academy of Sciences · 2008 · 1.2K citations · Full text

, , +17

Molecular-level secondary structure, polymorphism, and dynamics of full-length α-synuclein fibrils studied by solid-state NMR

Henrike Heise, Wolfgang Hoyer, Stefan Becker et al. · Proceedings of the National Academy of Sciences · 2005 · 639 citations · Full text

, , +17

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

Marius Kollmer, William Close, Leonie Funk et al. · Nature Communications · 2019 · 612 citations · Full text

, , +17

Peptide Conformation and Supramolecular Organization in Amylin Fibrils:  Constraints from Solid-State NMR

Sorin Luca, Wai‐Ming Yau, Richard D. Leapman et al. · Biochemistry · 2007 · 582 citations · Full text

, , +17

1–5 of 376

Authors

2.3K

  1. MS
    M.R. Sawaya

    University of California, Los Angeles, United States

    9 publications · 1.6K citations

    9

    h-index

  2. MD
    Merrill D. Benson

    Indiana University – Purdue University Indianapolis, United States

    9 publications · 820 citations

    9

    h-index

  3. DE
    David Eisenberg

    University of California, Los Angeles, United States

    8 publications · 1.6K citations

    8

    h-index

  4. SE
    Sheena E. Radford

    University of Leeds, United Kingdom

    8 publications · 543 citations

    8

    h-index

  5. TY
    Toshiyuki Yamada

    Jichi Medical University, Japan

    8 publications · 222 citations

    8

    h-index

1–5 of 2.3K

Institutions

853

  1. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    14 h-index

    32 publications

    3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    53 publications

    1.5K citations

  3. National Institutes of Health

    Bethesda, United States

    13 h-index

    45 publications

    10.1K citations

  4. ETH Zurich

    Zurich, Switzerland

    11 h-index

    29 publications

    1.6K citations

  5. University of California San Diego

    San Diego, United States

    10 h-index

    38 publications

    4K citations

  6. Linköping University

    Linköping, Sweden

    10 h-index

    36 publications

    1.8K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    10 h-index

    46 publications

    12K citations

  8. Indiana University School of Medicine

    Indianapolis, United States

    10 h-index

    24 publications

    2.3K citations

1–8 of 853

Venues

  1. Amyloid

    21 publications · 749 citations

    15

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 13 publications · 3.6K citations

    13

    h-index

  3. Scientific Reports

    11 publications · 320 citations

    11

    h-index

  4. Nature Communications

    11 publications · 1.3K citations

    11

    h-index

  5. Journal of the American Chemical Society

    JACS · 11 publications · 1.2K citations

    11

    h-index

1–5