Concepedia

Amide Hydrolysis

Amide Hydrolysis is a chemical reaction, classified as a nucleophilic acyl substitution, in which an amide undergoes cleavage in the presence of water under acidic or basic conditions to yield a carboxylic acid and an amine or ammonia.

1.1K

Publications

52.1K

Citations

3.8K

Authors

900

Institutions

Publications per year

2017–2026

105

Parents

Publications

1.1K

Mechanism of C-terminal amide formation by pituitary enzymes

A.F. Bradbury, M. D. A. FINNIE, D.G. Smyth · Nature · 1982 · 661 citations

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Two‐Metal Ion Catalysis in Enzymatic Acyl‐ and Phosphoryl‐Transfer Reactions

Norbert Sträter, William N. Lipscomb, Thomas Klabunde et al. · Angewandte Chemie International Edition in English · 1996 · 612 citations

, , +17

Converting Trypsin to Chymotrypsin: The Role of Surface Loops

Lizbeth Hedstrom, László Szilágyi, William J. Rutter · Science · 1992 · 470 citations

, , +17

Characterization of the Fatty Acid Amide Hydrolase Inhibitor Cyclohexyl Carbamic Acid 3′-Carbamoyl-biphenyl-3-yl Ester (URB597): Effects on Anandamide and Oleoylethanolamide Deactivation

Darren Fegley, Silvana Gaetani, Andrea Duranti et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 430 citations · Full text

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Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes

Vivek Anantharaman, L. Aravind · Genome biology · 2003 · 375 citations · Full text

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1–5 of 1.1K

Authors

3.8K

  1. JM
    John M. Buchanan

    Massachusetts Institute of Technology, United States

    36 publications · 2.4K citations

    33

    h-index

  2. BF
    Benjamin F. Cravatt

    Scripps Research Institute, United States

    16 publications · 1.9K citations

    14

    h-index

  3. MM
    Marco Mor

    University of Parma, Italy

    10 publications · 1.3K citations

    10

    h-index

  4. DP
    Daniele Piomelli

    University of California, Irvine, United States

    10 publications · 1.3K citations

    10

    h-index

  5. TN
    Tatjana N. Parac‐Vogt

    KU Leuven, Belgium

    9 publications · 501 citations

    9

    h-index

1–5 of 3.8K

Institutions

900

  1. Massachusetts Institute of Technology

    Cambridge, United States

    31 h-index

    91 publications

    6.4K citations

  2. Scripps Research Institute

    San Diego, United States

    22 h-index

    86 publications

    10.9K citations

  3. Kyoto University

    Kyoto, Japan

    13 h-index

    52 publications

    1.6K citations

  4. Harvard University

    Cambridge, United States

    12 h-index

    33 publications

    3.4K citations

  5. Pfizer (United States)

    New York, United States

    11 h-index

    70 publications

    6.2K citations

  6. KU Leuven

    Leuven, Belgium

    11 h-index

    41 publications

    1.7K citations

  7. University of Stuttgart

    Stuttgart, Germany

    10 h-index

    28 publications

    1.3K citations

  8. University of Pennsylvania

    Philadelphia, United States

    10 h-index

    26 publications

    1.7K citations

1–8 of 900

Venues

  1. Journal of Biological Chemistry

    JBC · 85 publications · 6.2K citations

    48

    h-index

  2. Journal of the American Chemical Society

    JACS · 96 publications · 5.2K citations

    43

    h-index

  3. Biochemistry

    38 publications · 2.1K citations

    26

    h-index

  4. The Journal of Organic Chemistry

    JOC · 35 publications · 1.3K citations

    19

    h-index

  5. Canadian Journal of Chemistry

    24 publications · 733 citations

    17

    h-index

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