Concepedia

Alpha-granule Secretion

Alpha-Granule Secretion is a platelet exocytosis process in which alpha-granules, the most abundant secretory organelles in platelets, release their bioactive cargo—including adhesive proteins, growth factors, and coagulation regulators—into the extracellular environment to facilitate platelet aggregation, wound healing, and thrombus stabilization during primary hemostasis.

367

Publications

27K

Citations

1.5K

Authors

421

Institutions

Publications per year

2017–2026

35

Parents

Publications

367

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation.

Paula E. Stenberg, Rodger P. McEver, Marc A. Shuman et al. · The Journal of Cell Biology · 1985 · 885 citations · Full text

, , +17

Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

Peter J. Sims, Elena M. Faioni, Therese Wiedmer et al. · Journal of Biological Chemistry · 1988 · 673 citations · Full text

, , +15

Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release.

Laurence A. Harker, Thomas W. Malpass, Herman Branson et al. · PubMed · 1980 · 663 citations

, , +17

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

T J Rink, Ana Sánchez, Trevor J. Hallam · Nature · 1983 · 591 citations

, , +16

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

Richard K. Assoian, Michael B. Sporn · The Journal of Cell Biology · 1986 · 542 citations · Full text

, , +13

1–5 of 367

Authors

1.5K

  1. SW
    Sidney W. Whiteheart

    University of Kentucky, United States

    13 publications · 1.2K citations

    12

    h-index

  2. DF
    D F Bainton

    University of California, San Francisco, United States

    10 publications · 1.7K citations

    10

    h-index

  3. RF
    Robert Flaumenhaft

    Beth Israel Deaconess Medical Center, United States

    10 publications · 651 citations

    10

    h-index

  4. JG
    James G. White

    University of Minnesota, United States

    9 publications · 925 citations

    9

    h-index

  5. HH
    Holm Holmsen

    University of Bergen, Norway

    8 publications · 300 citations

    8

    h-index

1–5 of 1.5K

Institutions

421

  1. Inserm

    Paris, France

    23 h-index

    136 publications

    11.8K citations

  2. Harvard University

    Cambridge, United States

    15 h-index

    44 publications

    4.2K citations

  3. McMaster University

    Hamilton, Canada

    13 h-index

    39 publications

    2.1K citations

  4. University of Kentucky

    Lexington, United States

    12 h-index

    50 publications

    4.2K citations

  5. Temple University

    Philadelphia, United States

    11 h-index

    42 publications

    1.7K citations

  6. Beth Israel Deaconess Medical Center

    Boston, United States

    11 h-index

    28 publications

    2.4K citations

  7. Hôpital Lariboisière

    Paris, France

    10 h-index

    43 publications

    5.3K citations

  8. University of California, San Francisco

    San Francisco, United States

    9 h-index

    28 publications

    7.2K citations

1–8 of 421

Venues

  1. Blood

    54 publications · 5.2K citations

    42

    h-index

  2. Journal of Biological Chemistry

    JBC · 24 publications · 3.1K citations

    24

    h-index

  3. PubMed

    Repository · 29 publications · 2.3K citations

    21

    h-index

  4. Thrombosis and Haemostasis

    21 publications · 1K citations

    16

    h-index

  5. Platelets

    17 publications · 402 citations

    13

    h-index

1–5