Concepedia

Alpha Spending Functions

Alpha spending function is a statistical method in sequential analysis that belongs to the class of error control procedures, specifically defining the cumulative Type I error expenditure over time in a manner that preserves the overall significance level across multiple interim analyses.

21

Publications

1.7K

Citations

69

Authors

63

Institutions

Publications per year

2017–2026

7

Variants

Alpha Spending Function

Parents

Publications

21

Interim analysis: The alpha spending function approach

David L. DeMets, K. K. Gordon Lan · Statistics in Medicine · 1994 · 569 citations

, , +11

Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer

Cora N. Sternberg, Karim Fizazi, Fred Saad et al. · New England Journal of Medicine · 2020 · 422 citations · Full text

, , +17

Apalutamide and Overall Survival in Prostate Cancer

Matthew R. Smith, Fred Saad, Simon Chowdhury et al. · European Urology · 2020 · 290 citations · Full text

, , +16

Interim Monitoring of Group Sequential Trials Using Spending Functions for the Type I and Type II Error Probabilities

S. Pampallona, Anastasios A. Tsiatis, KyungMann Kim · Drug Information Journal · 2001 · 67 citations

, , +17

Comparison of Bayesian and frequentist group-sequential clinical trial designs

Nigel Stallard, Susan Todd, Elizabeth Ryan et al. · BMC Medical Research Methodology · 2020 · 65 citations · Full text

, , +15

1–5 of 21

Authors

69

  1. RA
    Rebecca A. Betensky

    Harvard University, United States

    2 publications · 22 citations

    2

    h-index

  2. KK
    K. K. Gordon Lan

    National Heart Lung and Blood Institute, United States

    2 publications · 584 citations

    2

    h-index

  3. FS
    Fred Saad

    Université de Montréal, Canada

    2 publications · 712 citations

    2

    h-index

  4. KM
    Katharina Modelska

    University of California, San Francisco, United States

    1 publications · 422 citations

    1

    h-index

  5. HZ
    Han Zhu

    Tianjin University, China

    1 publications · 22 citations

    1

    h-index

1–5 of 69

Institutions

63

  1. Harvard University

    Cambridge, United States

    3 h-index

    2 publications

    302 citations

  2. University of Wisconsin–Madison

    Madison, United States

    2 h-index

    2 publications

    636 citations

  3. George Washington University

    Washington, United States

    2 h-index

    3 publications

    599 citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    2 h-index

    1 publications

    422 citations

  5. Pfizer (United States)

    New York, United States

    2 h-index

    4 publications

    1.3K citations

  6. University of Reading

    Reading, United Kingdom

    2 h-index

    2 publications

    87 citations

  7. Instituto de Investigación Biomédica de Málaga

    Málaga, Spain

    1 h-index

    1 publications

    290 citations

  8. Cal Humanities

    San Francisco, United States

    1 h-index

    1 publications

    49 citations

1–8 of 63

Venues

  1. Statistics in Medicine

    6 publications · 645 citations

    7

    h-index

  2. BMC Medical Research Methodology

    2 publications · 82 citations

    2

    h-index

  3. New England Journal of Medicine

    NEJM · 1 publications · 422 citations

    1

    h-index

  4. Journal of Biopharmaceutical Statistics

    JBS · 1 publications · 14 citations

    1

    h-index

  5. Statistical Applications in Genetics and Molecular Biology

    SAGMB · 1 publications · 12 citations

    1

    h-index

1–5