Concepedia

Alpha Cell Differentiation

Alpha Cell Differentiation is a developmental biological process in which multipotent pancreatic progenitor cells commit to the alpha cell lineage through specific transcriptional and signaling cascades, thereby acquiring the capacity to synthesize and secrete glucagon as a defining functional trait.

79

Publications

8K

Citations

453

Authors

141

Institutions

Publications per year

2017–2026

18

Parents

Publications

79

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

Fabrizio Thorel, Virginie Népote, Isabelle Avril et al. · Nature · 2010 · 1.1K citations · Full text

, , +14

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

Luc St‐Onge, Beatriz Sosa‐Pineda, Kamal Chowdhury et al. · Nature · 1997 · 778 citations

, , +13

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

Patrick Collombat, Xiaobo Xu, Philippe Ravassard et al. · Cell · 2009 · 542 citations · Full text

, , +16

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

Jan Jensen, R. Scott Heller, T Funder-Nielsen et al. · Diabetes · 2000 · 440 citations · Full text

, , +16

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

Tao Gao, Brian D. McKenna, Changhong Li et al. · Cell Metabolism · 2014 · 412 citations · Full text

, , +11

1–5 of 79

Authors

453

  1. JP
    Jacques Philippé

    University Hospital of Geneva, Switzerland

    7 publications · 438 citations

    7

    h-index

  2. YG
    Yvan Gosmain

    University Hospital of Geneva, Switzerland

    5 publications · 248 citations

    5

    h-index

  3. PC
    Patrick Collombat

    Max Planck Institute for Biophysical Chemistry, Germany

    4 publications · 985 citations

    4

    h-index

  4. PL
    Pedro L. Herrera

    University of Geneva, Switzerland

    4 publications · 1.6K citations

    4

    h-index

  5. AM
    Ahmed Mansouri

    Max Planck Institute for Biophysical Chemistry, Germany

    4 publications · 1.4K citations

    4

    h-index

1–5 of 453

Institutions

141

  1. University of Geneva

    Geneva, Switzerland

    11 h-index

    33 publications

    9.7K citations

  2. University Hospital of Geneva

    Geneva, Switzerland

    7 h-index

    31 publications

    2.2K citations

  3. University of Pennsylvania

    Philadelphia, United States

    6 h-index

    29 publications

    6.3K citations

  4. Inserm

    Paris, France

    6 h-index

    12 publications

    2.9K citations

  5. Max Planck Institute for Biophysical Chemistry

    Göttingen, Germany

    4 h-index

    12 publications

    5.1K citations

  6. Vanderbilt University Medical Center

    Nashville, United States

    4 h-index

    14 publications

    1.9K citations

  7. South African Medical Research Council

    Cape Town, South Africa

    3 h-index

    8 publications

    371 citations

  8. University of Pittsburgh

    Pittsburgh, United States

    3 h-index

    10 publications

    350 citations

1–8 of 141

Venues

  1. Diabetes

    7 publications · 1.1K citations

    7

    h-index

  2. Diabetologia

    6 publications · 261 citations

    6

    h-index

  3. Journal of Biological Chemistry

    JBC · 5 publications · 408 citations

    5

    h-index

  4. Endocrinology

    4 publications · 166 citations

    4

    h-index

  5. Metabolism

    3 publications · 52 citations

    3

    h-index

1–5