Concepedia

Allosteric Switch Design

Allosteric Switch Design is a protein engineering strategy that involves the rational construction of conformational control mechanisms in proteins, where the introduction of specific regulatory domains or mutations enables ligand-induced structural transitions that modulate functional activity at a distant site.

50

Publications

3.8K

Citations

288

Authors

107

Institutions

Publications per year

2017–2026

24

Parents

Publications

50

A chemical switch for inhibitor-sensitive alleles of any protein kinase

Anthony C. Bishop, Jeffrey A. Ubersax, Dejah T. Petsch et al. · Nature · 2000 · 1.1K citations

, , +15

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

Aron M. Levin, D.L. Bates, Aaron M. Ring et al. · Nature · 2012 · 554 citations

, , +14

De novo design of bioactive protein switches

Robert A. Langan, Scott E. Boyken, Andrew H. Ng et al. · Nature · 2019 · 284 citations · Full text

, , +12

Engineering extrinsic disorder to control protein activity in living cells

Onur Dağliyan, Mirosław Tarnawski, Pei-Hsuan Chu et al. · Science · 2016 · 251 citations · Full text

, , +17

Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP

Samuel W. Olson, Anne‐Marie W. Turner, J. Winston Arney et al. · Molecular Cell · 2022 · 115 citations · Full text

, , +8

1–5 of 50

Authors

288

  1. AV
    Andrei V. Karginov

    University of Illinois Chicago, United States

    2 publications · 73 citations

    2

    h-index

  2. KM
    Klaus M. Hahn

    University of North Carolina at Chapel Hill, United States

    2 publications · 269 citations

    2

    h-index

  3. VS
    Viktor Stein

    University of Cambridge, United Kingdom

    2 publications · 152 citations

    2

    h-index

  4. DB
    David Baker

    University of Washington, United States

    2 publications · 362 citations

    2

    h-index

  5. KA
    Kirill Alexandrov

    The University of Queensland, Australia

    2 publications · 107 citations

    2

    h-index

1–5 of 288

Institutions

107

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    4 h-index

    14 publications

    2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    6 publications

    1.5K citations

  3. University of California, San Francisco

    San Francisco, United States

    3 h-index

    14 publications

    5.8K citations

  4. The University of Texas Southwestern Medical Center

    Dallas, United States

    2 h-index

    5 publications

    228 citations

  5. Stanford University

    Stanford, United States

    2 h-index

    12 publications

    6.1K citations

  6. PDL BioPharma (United States)

    Incline Village, United States

    2 h-index

    4 publications

    518 citations

  7. The University of Queensland

    Brisbane, Australia

    2 h-index

    6 publications

    256 citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    7 publications

    309 citations

1–8 of 107

Venues

  1. Nature

    4 publications · 2K citations

    4

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 119 citations

    3

    h-index

  3. Journal of Biological Chemistry

    JBC · 3 publications · 100 citations

    3

    h-index

  4. Journal of the American Chemical Society

    JACS · 3 publications · 74 citations

    3

    h-index

  5. Molecular Cell

    2 publications · 173 citations

    2

    h-index

1–5