Concepedia

Allosteric Amplification

Allosteric Amplification is a signal amplification mechanism in which the binding of a molecule at an allosteric site enhances the activity or affinity of a primary functional site on a macromolecule, thereby propagating and amplifying a biological signal through conformational change.

21

Publications

1.3K

Citations

75

Authors

45

Institutions

Publications per year

2017–2026

5

Parents

Publications

21

Signal Amplification and Detection via a Supramolecular Allosteric Catalyst

Nathan C. Gianneschi, SonBinh T. Nguyen, Chad A. Mirkin · Journal of the American Chemical Society · 2005 · 188 citations

, , +17

Intercellular communication between artificial cells by allosteric amplification of a molecular signal

Bastiaan C. Buddingh’, Janneke Elzinga, Jan C. M. van Hest · Nature Communications · 2020 · 183 citations · Full text

, , +11

Molecular mechanism of the allosteric enhancement of the umami taste sensation

Ole G. Mouritsen, Himanshu Khandelia · FEBS Journal · 2012 · 137 citations · Full text

, , +17

Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenes.

Robert F. Bruns, James H. Fergus, Linda L. Coughenour et al. · Molecular Pharmacology · 1990 · 106 citations

, , +17

Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory

Detlef Balschun, Werner Zuschratter, Wolfram Wetzel · Neuroscience · 2006 · 93 citations

, , +16

1–5 of 21

Authors

75

  1. GF
    Gaku Fukuhara

    The University of Osaka, Japan

    2 publications · 36 citations

    2

    h-index

  2. GL
    Gerald L. Hazelbauer

    Washington State University, United States

    2 publications · 90 citations

    2

    h-index

  3. JH
    James H. Fergus

    Time Warner (United States), United States

    1 publications · 106 citations

    1

    h-index

  4. YY
    Yongpeng Yao

    Institute of Microbiology, China

    1 publications · 40 citations

    1

    h-index

  5. LA
    Ludmila A. Barnakova

    University of Missouri, United States

    1 publications · 31 citations

    1

    h-index

1–5 of 75

Institutions

45

  1. Japan Science and Technology Agency

    Tokyo, Japan

    2 h-index

    2 publications

    36 citations

  2. Tokyo Institute of Technology

    Tokyo, Japan

    2 h-index

    3 publications

    47 citations

  3. University of Missouri

    Columbia, United States

    2 h-index

    3 publications

    149 citations

  4. State Key Laboratory of Biology of Plant Diseases and Insect Pests

    Beijing, China

    1 h-index

    2 publications

    80 citations

  5. Northwestern University

    Evanston, United States

    1 h-index

    3 publications

    564 citations

  6. State Key Laboratory of Microbial Resources

    Beijing, China

    1 h-index

    6 publications

    240 citations

  7. Kyoto Prefectural University

    Kyoto, Japan

    1 h-index

    1 publications

    11 citations

  8. Leibniz Institute for Neurobiology

    Magdeburg, Germany

    1 h-index

    3 publications

    279 citations

1–8 of 45

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 91 citations

    2

    h-index

  2. Journal of the American Chemical Society

    JACS · 2 publications · 247 citations

    2

    h-index

  3. FEBS Journal

    1 publications · 137 citations

    1

    h-index

  4. Journal of Magnetic Resonance

    JMR · 1 publications · 12 citations

    1

    h-index

  5. Nature Structural & Molecular Biology

    1 publications · 48 citations

    1

    h-index

1–5