Concepedia

Aggregation-prone Sequence Elements

Aggregation-Prone Sequence Elements is a structural bioinformatics construct denoting specific short amino acid sequence motifs that, by virtue of their hydrophobicity, low net charge, and propensity for β-sheet formation, exhibit an elevated tendency to mediate protein misfolding and amyloid-like aggregation compared to other sequence elements.

73

Publications

7.2K

Citations

337

Authors

160

Institutions

Publications per year

2017–2026

24

Parents

Publications

73

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

Oscar Conchillo‐Solé, Natalia Sánchez de Groot, Francesc Avilés et al. · BMC Bioinformatics · 2007 · 1.1K citations · Full text

, , +17

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

Sebastian Maurer‐Stroh, Maja Debulpaep, Nico Kuemmerer et al. · Nature Methods · 2010 · 689 citations · Full text

, , +16

Prediction of “Aggregation-prone” and “Aggregation-susceptible” Regions in Proteins Associated with Neurodegenerative Diseases

Amol Pawar, Kateri F. DuBay, Jesús Zurdo et al. · Journal of Molecular Biology · 2005 · 585 citations

, , +17

The importance of sequence diversity in the aggregation and evolution of proteins

Caroline F. Wright, Sarah A. Teichmann, Jane Clarke et al. · Nature · 2005 · 320 citations

, , +12

Mutations that Reduce Aggregation of the Alzheimer's Aβ42 Peptide: an Unbiased Search for the Sequence Determinants of Aβ Amyloidogenesis

Christine Wurth, Nathalie K. Guimard, Michael H. Hecht · Journal of Molecular Biology · 2002 · 235 citations

, , +17

1–5 of 73

Authors

337

  1. SK
    Sandeep Kumar

    Pfizer (United States), United States

    7 publications · 383 citations

    7

    h-index

  2. JS
    Joost Schymkowitz

    KU Leuven, Belgium

    5 publications · 998 citations

    5

    h-index

  3. MM
    M. Michael Gromiha

    Indian Institute of Technology Madras, India

    4 publications · 100 citations

    4

    h-index

  4. SV
    Salvador Ventura

    Universitat Autònoma de Barcelona, Spain

    4 publications · 1.3K citations

    4

    h-index

  5. FC
    Fabrizio Chiti

    University of Florence, Italy

    4 publications · 860 citations

    4

    h-index

1–5 of 337

Institutions

160

  1. University of Florence

    Florence, Italy

    7 h-index

    14 publications

    1.4K citations

  2. Indian Institute of Technology Madras

    Chennai, India

    5 h-index

    10 publications

    271 citations

  3. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    5 h-index

    18 publications

    7K citations

  4. Pfizer (United States)

    New York, United States

    5 h-index

    11 publications

    1K citations

  5. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    12 publications

    4.1K citations

  6. KU Leuven

    Leuven, Belgium

    4 h-index

    31 publications

    2.2K citations

  7. Vrije Universiteit Brussel

    Brussels, Belgium

    3 h-index

    14 publications

    4.7K citations

  8. VIB-KU Leuven Center for Brain & Disease Research

    Leuven, Belgium

    3 h-index

    25 publications

    1.8K citations

1–8 of 160

Venues

  1. PLoS Computational Biology

    5 publications · 374 citations

    5

    h-index

  2. Journal of Molecular Biology

    JMB · 5 publications · 1.2K citations

    5

    h-index

  3. Nature Communications

    4 publications · 424 citations

    4

    h-index

  4. Biochemistry

    4 publications · 378 citations

    4

    h-index

  5. Proteins Structure Function and Bioinformatics

    4 publications · 222 citations

    4

    h-index

1–5